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Neuropathic tremor associated with anti-MAG IgM-monoclonal gammopathy and prostate adenocarcinoma: Which one is the culprit?

Neuropathic tremor is defined as tremor that occurs in association with peripheral neuropathy in the absence of any other neurological disorder. Certain peripheral neuropathies, especially demyelinating polyneuropathies, are more prone to development of tremor than others [1]. We report on a patient with sensorimotor demyelinating polyneuropathy associated with prostate adenocarcinoma and IgM monoclonal gammopathy of undetermined significance (IgM-MGUS) with high titres of anti-myelin-associated glycoprotein (MAG), presenting with upper limbs tremor and mild gait instability, who had a good response to treatment of underlying malignancy.

Tremor ; Polyneuropathy ; Prostate cancer ; Paraneoplastic syndrome

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