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Pregled bibliografske jedinice broj: 104235

In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells


Groc, Laurent; Petanjek, Zdravko; Gustafsson, Bengt; Ben-Ari, Yehezkel; Hanse, Eric; Khazipov, Ronstem
In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells // European journal of neuroscience, 16 (2002), 10; 1931-1938 (međunarodna recenzija, članak, znanstveni)


Naslov
In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells

Autori
Groc, Laurent ; Petanjek, Zdravko ; Gustafsson, Bengt ; Ben-Ari, Yehezkel ; Hanse, Eric ; Khazipov, Ronstem

Izvornik
European journal of neuroscience (0953-816X) 16 (2002), 10; 1931-1938

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CA1

Sažetak
During development, neural activity has been proposed to promote neuronal growth. During the first postnatal week, the hippocampus is characterized by an oscillating neural network activity and a rapid neuronal growth. In the present study we tested in vivo, by injecting tetanus toxin into the hippocampus of P1 rats, whether this neural activity indeed promotes growth of pyramidal cells. We have previously shown that tetanus toxin injection leads to a strong reduction in the frequency of spontaneous GABA and glutamatergic synaptic currents, and to a complete blockade of the early neural network activity during the first postnatal week. Morphology of neurobiotin-filled CA1 pyramidal cells was analyzed at the end of the first postnatal week (P6– 10). In activity-reduced neurons, the total length of basal dendritic tree was three times less than control. The number, but not the length, of basal dendritic branches was affected. The growth impairment was restricted to the basal dendrites. The apical dendrite, the axons, or the soma grew normally during activity deprivation. Thus, the in vivo neural activity in the neonate hippocampus seems to promote neuronal growth by initiating novel branches

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108118

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravko Petanjek (autor)

Citiraj ovu publikaciju

Groc, Laurent; Petanjek, Zdravko; Gustafsson, Bengt; Ben-Ari, Yehezkel; Hanse, Eric; Khazipov, Ronstem
In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells // European journal of neuroscience, 16 (2002), 10; 1931-1938 (međunarodna recenzija, članak, znanstveni)
Groc, L., Petanjek, Z., Gustafsson, B., Ben-Ari, Y., Hanse, E. & Khazipov, R. (2002) In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells. European journal of neuroscience, 16 (10), 1931-1938.
@article{article, year = {2002}, pages = {1931-1938}, keywords = {CA1}, journal = {European journal of neuroscience}, volume = {16}, number = {10}, issn = {0953-816X}, title = {In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells}, keyword = {CA1} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus