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Pregled bibliografske jedinice broj: 1042208

Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS


Popović Hadžija, Marijana; Siketić, Zdravko; Hadžija, Mirko; Barac, Marko; Bogdanović Radović, Ivančica
Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS // Diabetes research and clinical practice, 159 (2020), 107986, 9 doi:10.1016/j.diabres.2019.107986 (međunarodna recenzija, članak, ostalo)


Naslov
Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS

Autori
Popović Hadžija, Marijana ; Siketić, Zdravko ; Hadžija, Mirko ; Barac, Marko ; Bogdanović Radović, Ivančica

Izvornik
Diabetes research and clinical practice (0168-8227) 159 (2020); 107986, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Lipids ; Liver ; Serum ; Diabetes ; MeV TOF-SIMS

Sažetak
Aims: Hepatic insulin resistance, induced by fat, occurs before peripheral resistance and leads to prediabetes and diabetes. If insulin resistance is detected earlier, lifestyle changes could prevent or delay disease development. Therefore, we analysed lipids in the liver and serum of prediabetic and diabetic mice by MeV TOF-SIMS with a focus on diacylglycerols (DAGs) as the best predictor of (liver) resistance. Methods: Glucose impairment was spontaneously developed or induced by HFD in NOD/LtJ mice, and prediabetic and diabetic mice were selected according to their glucose levels. MeV TOF-SIMS was applied to image the lipid distribution in the liver and to relatively quantify lipids related to insulin resistance in both the liver and serum. Results: The same lipids were detected in the liver and serum but with different intensities between mice. The intensity of DAGs and fatty acids was higher in the diabetic than that in the prediabetic liver. Imaging of liver tissue showed a more compact density of prediabetic (non-fatty) than diabetic liver with DAG remodelling in diabetes. DAGs, which are greatly increased in diabetic serum, were successfully detected and quantified already in prediabetes. Conclusion: MeV TOF-SIMS applied to the serum presents an excellent tool for in vivo monitoring of disease development over time.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-1698 - Razvoj kapilarne mikroprobe za MeV SIMS s primjenom na analizu bioloških materijala (Ivančica Bogdanović Radović, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Popović Hadžija, Marijana; Siketić, Zdravko; Hadžija, Mirko; Barac, Marko; Bogdanović Radović, Ivančica
Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS // Diabetes research and clinical practice, 159 (2020), 107986, 9 doi:10.1016/j.diabres.2019.107986 (međunarodna recenzija, članak, ostalo)
Popović Hadžija, M., Siketić, Z., Hadžija, M., Barac, M. & Bogdanović Radović, I. (2020) Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS. Diabetes research and clinical practice, 159, 107986, 9 doi:10.1016/j.diabres.2019.107986.
@article{article, year = {2020}, pages = {9}, DOI = {10.1016/j.diabres.2019.107986}, chapter = {107986}, keywords = {Lipids, Liver, Serum, Diabetes, MeV TOF-SIMS}, journal = {Diabetes research and clinical practice}, doi = {10.1016/j.diabres.2019.107986}, volume = {159}, issn = {0168-8227}, title = {Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS}, keyword = {Lipids, Liver, Serum, Diabetes, MeV TOF-SIMS}, chapternumber = {107986} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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