Perinatal growth of prefrontal layer III pyramids in Down syndrome (CROSBI ID 98321)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vukšić, Mario ; Petanjek, Zdravko ; Rašin, Mladen-Roko ; Kostović, Ivica
engleski
Perinatal growth of prefrontal layer III pyramids in Down syndrome
We analyzed the dendritic differentiation of layer IIIc pyramidal neurons of prefrontal cortex (prospective area 9) in the brains of a premature infant and a 2.5-month-old infant with Down syndrome and two age-matched control subjects during the peak period of dendritic growth and differentiation. Our quantitative analysis supports qualitative observation and revealed no significant differences in the tempo and mode of dendritic differentiation between normal and Down syndrome cases. Thus we have concluded that the children with Down syndrome from our study begin their lives with morphologically normal layer III pyramidal neurons. Our findings suggest that pathologic changes of key prefrontal input-output neuronal elements begin to develop in Down syndrome after 2.5 months of postnatal age.
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti