engleski

Evaluation of pharmacological treatment efficacy and short-term mortality in patients with status epilepticus at Požega General County Hospital, Požega, Croatia

Objective: To determine efficacy of pharmacological treatment and short-term mortality in patients with status epilepticus (SE). Methods: This retrospective study included 109 episodes of SE recorded in 102 patients aged 18 years or older admitted to Požega General County Hospital during the period from January 1, 2006 until December 31, 2015. Patients were followed up on day 30 after SE onset to assess their living status. Results: Among 102 patients, 52 (51.0%) patients had a history of prior epilepsy. Initial antiepileptic drug was intravenous diazepam in 109 SE episodes. Of these, 97 (89.0%) SE episodes resolved with first- or second-line therapy (diazepam, phenobarbital, levetiracetam). For 12 (11.0%) SE episodes, thirdline therapy (midazolam, propofol) was administered. Of these, eight (7.3%) SE were classified as refractory status epilepticus (RSE) and four (3.7%) as super-refractory status epilepticus (super- RSE). Out of 102 patients, nine (8.8%) patients died within 30 days after SE. All patients died during their hospital stay. Five (55.6%) patients died due to the underlying disease and four (44.4%) patients died from clinical complications. Age and negative history of epilepsy were not predictors of mortality (p=0.321 and p=0.191, respectively). Conclusions: The SE mortality rate was lower than reported in previous studies and was not related to age and negative history of epilepsy. SE resolved with first- or second- line therapy in nine of ten patients.

status epilepticus ; therapy ; mortality rate

nije evidentirano