engleski

Carbamazepine-induced hypersensitivity reactions: case report

Background: Antiepileptic drugs can cause adverse cutaneous drug reactions. Most of the adverse cutaneous reactions have a favorable course, but there are serious cutaneous drug reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms. Case report: This paper presents a case of a 63- year-old male patient with ventriculoperitoneal shunt implanted six years before due to hydrocephalus, and treated at Department of Neurology in April 2014 for intracerebral hematoma in the left temporobasal region, which caused the first generalized tonic-clonic epileptic seizure. Carbamazepine was introduced in a daily oral dose of 400 mg. Five weeks after therapy initiation, he presented with generalized maculopapular exanthema and facial edema. Leukocytosis and monocytosis were verified on the second day of rash onset. He felt weakness on day 10 of rash onset, and high transaminase levels were recorded, increasing steadily for the next 10 days. Complete regression of rash occurred one month after carbamazepine discontinuation and corticosteroid therapy administration ; his laboratory findings normalized after four months. Conclusion: Persistence of generalized maculopapular rash, facial edema, hematologic abnormalities, and toxic lesion of the liver suggest a hypersensitivity reaction to carbamazepine.

hypersensitivity reactions ; carbamazepine ; epilepsy

nije evidentirano