engleski

Relationship between suicidality and thyreotropic axis activity.

Abstract Background: Investigation of the relationship between suicidality and the activity of thyreotropis axes is scarce, and has yielded conflicting results. The aim of this study was to examine the correlation between thyroid hormone levels and psychopathology (i.e. different mental disorders and suicidality). Method: A total of 424 adult psychiatric inpatients (81.1% female ; mean age 43.52 years) participated in this study. The occurrence of the predominant primary diagnoses were as follows: schizophrenia, schizotypal and delusional disorders (34.2%), mood disorders (29.7%), neurotic, stress-related and somatoform disorders (17.5%), personality disorders (8.3%), organic mental disorders (5.7%), and intentional self-harm (4.7%). Thyroid data was collected from medical records since January 2016 to March 2017. Results: Significant differences were obtained across different diagnostic categories (Kruskal-Wallis test) in relation to T3 and free T4 hormones: patients with organic mental disorders had significantly lower values of T3 hormone compared to other patients ; patients with personality disorders had significantly lower values of free T4 hormone (except when compared to patients with mood disorders), and patients with mood disorders had lower values of free T4 hormone compared to patients with psychotic disorders, patients with organic mental disorders and those who attempted suicide. Additionally, patients with organic mental disorders had similar values of TSH hormone as patients who attempted suicide, but these values were significantly lower compared to other patients. Conclusions: The findings showed different thyroid hormone levels in different mental disorders, including altered values of free T4 hormone in suicidal patients. Thus, the results suggest the possibility to determine these hormones as markers of suicidal ideation in psychiatric patients.

attempted suicide ; thyroid hormone

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