engleski

There are no differences in IL-6, CRP and homocystein concentrations between female descendants with or without a family history of AD

Background: Alzheimer disease (AD) is most present among dementias. A wide range of recent studies have detected inflammation as one of the most influent factors in the appearance and spreading of neurodegenerative brain diseases. Metods: We aimed to understand the influence of IL-6, CRP and homocysteine on 55 female patients suffering from AD, 51 midlle-aged daughters of the diseased patients, and 53 midlle-aged subjects without positive family history of AD. Results: The results of the conducted research are in accordance with the present scientific knowledge, thus a statistically significant difference for examined parameters has been determined between women suffering from AD and their midlle-aged daughters and midlle-aged subjects without positive family history of AD. There were no significant difference in hsCRP (p=0.601), IL- 6 (p=0.582) and Hcy (p=0.188) concentrations between female descendants with or without a family history of AD. There are obtained positive correlation between IL-6 and hsCrp and IL-6 and Hcy in AD patients while there is no such correlation between female subjects with or without a family history of AD. Conclusion: Obtained results indicate that the increased concentration of inflammatory factors and Hcy in AD patients is a symptomatic rather that causal factor. These findings of an association between Hcy and IL-6 levels and between IL-6 and hsCrp, support the hypothesis that Hcy stimulates low-grade inflammation. However, our finding that there is a lack of correlation between Hcy and CRP in AD patients suggests that Hcy levels may not be a simple reflection of inflammation.

Alzheimer disease ; IL-6 ; CRP ; homocysteine

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