engleski

Interaction analyses of AChE and BChE with selected pesticides

Intoxication monitoring and intervention solution for pesticides intoxication are essential issues for public health surveillance and control world-wildly. The well-known action mechanism for OP pesticides intoxication is through the inhibition of acetylcholinesterase (AChE), an enzyme critical for cholinergic neurotransmission. Disruption of AChE biosynthesis process by certain pesticides has been evidenced, and was considered as one of the mechanisms for the long-term effects of these compounds. Thus, in order to fully understand the action of these pesticides, their effects and mechanisms on both AChE expression and enzymatic activity merit in- depth investigations. The objectives was to reveal the alterations in the enzymatic activity and expression of AChE caused by selected pesticides (Metamiphos, Phenamidophos, Ethoprophos, Phosalone, and Acetamiprid), to investigate the action mechanisms by in silico methods, and to elucidate cell signaling mechanisms for the AChE dysregulation.

Organophosphorous pesticides ; cholinesterase inhibition ; molecular modeling

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