Naslov
Platelet indices as inflammatory markers in stable COPD

Autori
Hlapčić, Iva ; Grdić Rajković, Marija ; Hulina Tomašković, Andrea ; Somborac Bačura, Anita ; Rako, Ivana ; Vukić Dugac, Andrea ; Rumora, Lada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ERS International Congress 2019 / - Madrid, 2019, 395-395

Skup
ERS International Congress 2019

Mjesto i datum
Madrid, Španjolska, 28.09.2019. - 02.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
COPD, platelets, MPV, PDW, PLR

Sažetak
Introduction: Chronic obstructive pulmonary disease (COPD) is a condition with underlying systemic inflammation and haemostatic changes. Aims and objectives: Assessment of the platelet indices - platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet to lymphocyte ratio (PLR), evaluation of their diagnostic value and association with well-known inflammatory markers. Methods: 109 patients with stable COPD and 95 healthy controls were included. Blood samples were collected in different tubes depending on the analysis. The results were analyzed by Mann-Whitney Rank Sum test performed by MedCalc statistical software. Results: Among platelet indices, PLT (P=0.007) and PLR (P=0.005) were significantly increased, while MPV (P<0.001) and PDW (P<0.001) were decreased in COPD patients. Inflammatory markers, CRP (P<0.001), fibrinogen (P<0.001) and leukocyte count (P<0.001) were increased in COPD patients. Positive correlation between fibrinogen and platelet count was observed (r=0.396, P<0.001). Moreover, fibrinogen showed to be a good diagnostic predictor of COPD (OR=2.5529, P<0.001). Leukocyte count, PDW and PLR correctly classified 75% of COPD cases with an AUC of 0.845 in a multivariate logistic regression analysis. Conclusions: Our study suggests that thrombocytosis is present in chronic inflammation observed in COPD patients. Fibrinogen may be useful as a COPD predictor. Due to its association with PLT, it confirmed systemic inflammation and haemostatic changes in COPD. Moreover, PLT showed a good performance as a COPD predictor when combined with lymphocytes in a ratio. Model combining PLR, PDW and leukocyte count has good discrimination power among healthy subjects and COPD patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA