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Pregled bibliografske jedinice broj: 1037966

Platelet indices as inflammatory markers in stable COPD


Hlapčić, Iva; Grdić Rajković, Marija; Hulina Tomašković, Andrea; Somborac Bačura, Anita; Rako, Ivana; Vukić Dugac, Andrea; Rumora, Lada
Platelet indices as inflammatory markers in stable COPD // ERS International Congress 2019
Madrid, 2019. str. 395-395 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1037966 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Platelet indices as inflammatory markers in stable COPD

Autori
Hlapčić, Iva ; Grdić Rajković, Marija ; Hulina Tomašković, Andrea ; Somborac Bačura, Anita ; Rako, Ivana ; Vukić Dugac, Andrea ; Rumora, Lada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ERS International Congress 2019 / - Madrid, 2019, 395-395

Skup
ERS International Congress 2019

Mjesto i datum
Madrid, Španjolska, 28.09.– 02.10.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
COPD, platelets, MPV, PDW, PLR

Sažetak
Introduction: Chronic obstructive pulmonary disease (COPD) is a condition with underlying systemic inflammation and haemostatic changes. Aims and objectives: Assessment of the platelet indices - platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet to lymphocyte ratio (PLR), evaluation of their diagnostic value and association with well-known inflammatory markers. Methods: 109 patients with stable COPD and 95 healthy controls were included. Blood samples were collected in different tubes depending on the analysis. The results were analyzed by Mann-Whitney Rank Sum test performed by MedCalc statistical software. Results: Among platelet indices, PLT (P=0.007) and PLR (P=0.005) were significantly increased, while MPV (P<0.001) and PDW (P<0.001) were decreased in COPD patients. Inflammatory markers, CRP (P<0.001), fibrinogen (P<0.001) and leukocyte count (P<0.001) were increased in COPD patients. Positive correlation between fibrinogen and platelet count was observed (r=0.396, P<0.001). Moreover, fibrinogen showed to be a good diagnostic predictor of COPD (OR=2.5529, P<0.001). Leukocyte count, PDW and PLR correctly classified 75% of COPD cases with an AUC of 0.845 in a multivariate logistic regression analysis. Conclusions: Our study suggests that thrombocytosis is present in chronic inflammation observed in COPD patients. Fibrinogen may be useful as a COPD predictor. Due to its association with PLT, it confirmed systemic inflammation and haemostatic changes in COPD. Moreover, PLT showed a good performance as a COPD predictor when combined with lymphocytes in a ratio. Model combining PLR, PDW and leukocyte count has good discrimination power among healthy subjects and COPD patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za plućne bolesti "Jordanovac",
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Hlapčić, Iva; Grdić Rajković, Marija; Hulina Tomašković, Andrea; Somborac Bačura, Anita; Rako, Ivana; Vukić Dugac, Andrea; Rumora, Lada
Platelet indices as inflammatory markers in stable COPD // ERS International Congress 2019
Madrid, 2019. str. 395-395 (poster, međunarodna recenzija, sažetak, znanstveni)
Hlapčić, I., Grdić Rajković, M., Hulina Tomašković, A., Somborac Bačura, A., Rako, I., Vukić Dugac, A. & Rumora, L. (2019) Platelet indices as inflammatory markers in stable COPD. U: ERS International Congress 2019.
@article{article, year = {2019}, pages = {395-395}, keywords = {COPD, platelets, MPV, PDW, PLR}, title = {Platelet indices as inflammatory markers in stable COPD}, keyword = {COPD, platelets, MPV, PDW, PLR}, publisherplace = {Madrid, \v{S}panjolska} }




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