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Pregled bibliografske jedinice broj: 1035666

ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019


Krivohlavek, Adela; Kosić Vukšić, Josipa; Ivešić, Martina; Žuntar, Irena; Šikić, Sandra
ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019 // 9th International Symposium on RAFA / Pulkrabová, Jana ; Tomaniová, Monika ; Nielen, Michel ; Hajšlová, Jana (ur.).
Prague: University of Chemistry and Technology, Prague, 2019. str. 281-281 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1035666 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019

Autori
Krivohlavek, Adela ; Kosić Vukšić, Josipa ; Ivešić, Martina ; Žuntar, Irena ; Šikić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

ISBN
978-80-7592-055-3

Skup
9th International Symposium on RAFA

Mjesto i datum
Prag, Češka, 05.-08.11.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PDE-5 inhibitors, analogues, herbal dietary supplements, High-Performance Liquid Chromatography (HPLC), time of flight mass spectrophotometer (TOF-MS

Sažetak
Erectile dysfunction (ED) is a condition in which man are unable to achieve or maintain an erection firm enough for satisfactory sexual intercourse. Synthetic phosphodiesterase type 5 (PDE-5) inhibitors are widely used for treatment of erectile dysfunction. There are four PDE5 inhibitors approved for treatment in Europe and the United States: avanafil, sildenafil, tadalafil and vardenafil. In order to protect the public from fraudulent practices, adequate methods for dietary monitoring should be enforced. This includes screening methods and strategies for the identification of new and unapproved compounds, while focusing on quantification of adulterants. The aim of this study was to investigate herbal dietary supplements sold on the Croatian market for the presence of PDE5 inhibitors and their analogues in period 2012-2019. In this study, dietary supplements and herbal matrices of different forms collected from the Croatian market (pharmacies and store) were analyzed by LC–ESI–MS/MS or by HPLC-TOF-MS. Methods have been validated in terms of specificity, precision, accuracy, detection and quantification limits, linearity, stability and recovery. Three different forms of blank samples, pills, capsules and honey were used in the validation process. Validation parameters meet all acceptance criteria. PDE5 inhibitors were analyzed in 94 samples by method LC–ESI–MS/MS 57 samples in the period 2012-2013, 37 samples in the period 2014-2016, and 35 samples were analyzed by HPLC-TOF-MS in the period 2017-2019, of which 11, 15 and 19 were positive, respectively. Using a more sophisticated technique and examination of unknown substances, an increase in positive samples was observed from 19%, 41% and 54% respectively. In the case of positive samples, sildenafil and tadalafil in tablet combination were most commonly detected. As a conclusion adulteration of supplements with PDE-5 inhibitors and their analogues is extremely dangerous for consumers due to the unknown efficacy and toxic effects and should be inspected.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita, Farmacija



POVEZANOST RADA


Projekti:
KK.01.1.1.02.0004 - Centar za sigurnost i kvalitetu hrane (EK - KK.01.1.1.02) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar"

Poveznice na cjeloviti tekst rada:

www.rafa2019.eu

Citiraj ovu publikaciju:

Krivohlavek, Adela; Kosić Vukšić, Josipa; Ivešić, Martina; Žuntar, Irena; Šikić, Sandra
ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019 // 9th International Symposium on RAFA / Pulkrabová, Jana ; Tomaniová, Monika ; Nielen, Michel ; Hajšlová, Jana (ur.).
Prague: University of Chemistry and Technology, Prague, 2019. str. 281-281 (poster, međunarodna recenzija, sažetak, znanstveni)
Krivohlavek, A., Kosić Vukšić, J., Ivešić, M., Žuntar, I. & Šikić, S. (2019) ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019. U: Pulkrabová, J., Tomaniová, M., Nielen, M. & Hajšlová, J. (ur.)9th International Symposium on RAFA.
@article{article, author = {Krivohlavek, Adela and Kosi\'{c} Vuk\v{s}i\'{c}, Josipa and Ive\v{s}i\'{c}, Martina and \v{Z}untar, Irena and \v{S}iki\'{c}, Sandra}, year = {2019}, pages = {281-281}, keywords = {PDE-5 inhibitors, analogues, herbal dietary supplements, High-Performance Liquid Chromatography (HPLC), time of flight mass spectrophotometer (TOF-MS}, isbn = {978-80-7592-055-3}, title = {ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019}, keyword = {PDE-5 inhibitors, analogues, herbal dietary supplements, High-Performance Liquid Chromatography (HPLC), time of flight mass spectrophotometer (TOF-MS}, publisher = {University of Chemistry and Technology, Prague}, publisherplace = {Prag, \v{C}e\v{s}ka} }
@article{article, author = {Krivohlavek, Adela and Kosi\'{c} Vuk\v{s}i\'{c}, Josipa and Ive\v{s}i\'{c}, Martina and \v{Z}untar, Irena and \v{S}iki\'{c}, Sandra}, year = {2019}, pages = {281-281}, keywords = {PDE-5 inhibitors, analogues, herbal dietary supplements, High-Performance Liquid Chromatography (HPLC), time of flight mass spectrophotometer (TOF-MS}, isbn = {978-80-7592-055-3}, title = {ANALYSIS OF UNDECLARED SYNTHETIC PHOSPHODIESTERASE-5 INHIBITORS IN DIETARY SUPPLEMENTS AND HERBAL MATRICES BY LC–ESI–MS/MS AND BY LC-TOF ON MARKET IN PERIOD 2012-2019}, keyword = {PDE-5 inhibitors, analogues, herbal dietary supplements, High-Performance Liquid Chromatography (HPLC), time of flight mass spectrophotometer (TOF-MS}, publisher = {University of Chemistry and Technology, Prague}, publisherplace = {Prag, \v{C}e\v{s}ka} }




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