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Pregled bibliografske jedinice broj: 1034903

CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice


Brizić, Ilija; Hiršl, Lea; Šustić, Marko; Golemac, Mijo; Britt William J.; Krmpotić Astrid; Jonjić Stipan
CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice // Medical microbiology and immunology, 208 (2019), 3-4; 487-494 doi:10.1007/s00430-019-00601-0 (međunarodna recenzija, članak, znanstveni)


Naslov
CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice

Autori
Brizić, Ilija ; Hiršl, Lea ; Šustić, Marko ; Golemac, Mijo ; Britt William J. ; Krmpotić Astrid ; Jonjić Stipan

Izvornik
Medical microbiology and immunology (0300-8584) 208 (2019), 3-4; 487-494

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mouse cytomegalovirus ; Tissue-resident memory T cells ; Brain pathology ; CD4 T cells ; Congenital CMV infection

Sažetak
Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and sensorineural hearing loss. Immune protection against mouse cytomegalovirus (MCMV) is primarily mediated by NK cells and CD8+ T cells, while CD4+ T cells are not needed for control of MCMV in majority of organs in immunocompetent adult mice. Here, we set out to determine the role of CD4+ T cells upon MCMV infection of newborn mice. We provide evidence that CD4+ T cells are essential for clearance of MCMV infection in brain of neonatal mice and for prevention of recurrence of latent MCMV. In addition, we provide evidence that CD4+ T cells are required for induction and maintenance of tissue- resident memory CD8+ T cells in the brain of mice perinatally infected with MCMV.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Citiraj ovu publikaciju

Brizić, Ilija; Hiršl, Lea; Šustić, Marko; Golemac, Mijo; Britt William J.; Krmpotić Astrid; Jonjić Stipan
CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice // Medical microbiology and immunology, 208 (2019), 3-4; 487-494 doi:10.1007/s00430-019-00601-0 (međunarodna recenzija, članak, znanstveni)
Brizić, I., Hiršl, L., Šustić, M., Golemac, M., Britt William J., Krmpotić Astrid & Jonjić Stipan (2019) CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice. Medical microbiology and immunology, 208 (3-4), 487-494 doi:10.1007/s00430-019-00601-0.
@article{article, year = {2019}, pages = {487-494}, DOI = {10.1007/s00430-019-00601-0}, keywords = {Mouse cytomegalovirus, Tissue-resident memory T cells, Brain pathology, CD4 T cells, Congenital CMV infection}, journal = {Medical microbiology and immunology}, doi = {10.1007/s00430-019-00601-0}, volume = {208}, number = {3-4}, issn = {0300-8584}, title = {CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice}, keyword = {Mouse cytomegalovirus, Tissue-resident memory T cells, Brain pathology, CD4 T cells, Congenital CMV infection} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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