CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice (CROSBI ID 271411)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Brizić, Ilija; Hiršl, Lea; Šustić, Marko; Golemac, Mijo; Britt, William J; Krmpotić, Astrid
engleski
CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn mice
Cytomegalovirus (CMV) infection is a significant public health problem. Congenital CMV infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and sensorineural hearing loss. Immune protection against mouse cytomegalovirus (MCMV) is primarily mediated by NK cells and CD8+ T cells, while CD4+ T cells are not needed for control of MCMV in majority of organs in immunocompetent adult mice. Here, we set out to determine the role of CD4+ T cells upon MCMV infection of newborn mice. We provide evidence that CD4+ T cells are essential for clearance of MCMV infection in brain of neonatal mice and for prevention of recurrence of latent MCMV. In addition, we provide evidence that CD4+ T cells are required for induction and maintenance of tissue- resident memory CD8+ T cells in the brain of mice perinatally infected with MCMV.
Mouse cytomegalovirus ; Tissue-resident memory T cells ; Brain pathology ; CD4 T cells ; Congenital CMV infection
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
208 (3-4)
2019.
487-494
objavljeno
0300-8584
1432-1831
10.1007/s00430-019-00601-0
Povezanost rada
Temeljne medicinske znanosti