engleski

Functional food in cardiovascular protection- effects of n-3 polyunsaturated fatt acids

Functional food is a food of natural origin that contains ingredients beneficial for human health when consumed in normal daily amounts. Potential beneficial effects of dietary daily intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) on various cardiovascular parameters are currently intensively investigated, particularly their role in vasoreactivity in macrocirculation and hemorrheological characteristic of the blood (for possible antithrombotic and atherosclerotic effects) and microcirculation (such as coronary and systemic microcirculation), investigating molecular targets related to endothelial function, e.g. endothelial or vascular smooth muscle cell ion channels, components of cellular and systemic oxidative stress/antioxidative system and the vasoactive effects of eicosanoids-metabolites of n-3 PUFAs and arachidonic acid. Inflammation underlies all cardiometabolic diseases. It has been suggested that n-3 PUFAs dietary intake can significantly attenuate inflammatory processes, contributing to maintaining healthy vascular function. Integrating the knowledge on molecular and physiological mechanisms potentially involved in vascular function is important for understanding etiopathogenesis of cardiovascular diseases and translation of research to clinical settings, to obtain medical treatment based on evidences. Hereby, the recent data on the effects of dietary n-3 PUFAs intake in form of enriched eggs on vascular function and immune system in healthy persons and cardiovascular patients is going to be presented. Acknowledgement: supported by European Structural and Investment Funds, grant for the Croatian National Scientific Center of Excellence for Personalized Health Care, University Josip Juraj Strossmayer Osijek #KK.01.1.1.01.0010.

n-3 PUFAs, enriched eggs, microcirculation

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