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Effects of oral L-carnitine supplementation on human serum fatty acid composition in healthy subjects


Delaš, Ivančica; Dražić, Tonko; Stojaković, Stjepan; Čačić Hribljan, Melita; Delaš, Marija
Effects of oral L-carnitine supplementation on human serum fatty acid composition in healthy subjects // Novel Approaches in Food Industry NAFI 2014 / Tavman, Şebnem ; (ur.).
Bornova, Izmir: Üniversiteliler Ofset, 2014. str. 176-176 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Effects of oral L-carnitine supplementation on human serum fatty acid composition in healthy subjects

Autori
Delaš, Ivančica ; Dražić, Tonko ; Stojaković, Stjepan ; Čačić Hribljan, Melita ; Delaš, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Novel Approaches in Food Industry NAFI 2014 / Tavman, Şebnem ; - Bornova, Izmir : Üniversiteliler Ofset, 2014, 176-176

ISBN
978-605-338-069-6

Skup
International Food Congress Novel Approaches in Food Industry NAFI 2014

Mjesto i datum
Kusadasi, Turska, 26-29. 05. 2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Carnitine, fatty acid composition, body mass reduction

Sažetak
Introduction L-Carnitine, L-(-)-β-hydroxy-γ-trimethylaminobutyrate, plays an important role in the transport of long-chain fatty acids into the mitochondria. It is speculated that carnitine administration, by promoting beta-oxidation, might improve exercise endurance, reduce the reliance on endogenous carbohydrate stores in athletes and promote body mass reduction. The aim of the study was to investigated whether L-carnitine supplementation would result in body mass reduction and/or influence the fatty acid composition in blood of healthy sedentary subjects. Methods A double-blind, placebo controlled study was carried out on 36 healthy volunteers with declared sedentary activities. They were divided into two groups: one received 2 g of L-carnitine supplement and the other an identically appearing placebo for 2 weeks. Blood samples were taken before and after supplementation and fatty acid composition was determined by gas chromatography. Anthropometric measurements were taken and nutritional intake was followed. Results Carnitine supplementation did not result in a body mass reduction. A significant decrease in the ratio of docosahexaenoic acid (C22:6n-3) with concomitant increase in linoleic (C18:2n-6) and linolenic acid (C18:3) levels was found in carnitine supplemented compared to control group. The ratio of other fatty acids was not affected. Conclusion In healthy sedentary subjects carnitine supplementation does not promote body mass reduction. The observed changes in fatty acid composition might indicate reduced utilization of essential fatty acids in beta-oxidation. For clear elucidation further studies are necessary.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija



POVEZANOST RADA


Projekt / tema
0108068

Ustanove
Medicinski fakultet, Zagreb