engleski

Alterations of regional cerebral blood flow and emotional recognition in patients with first episode psychosis

Introduction: Alterations of regional cerebral blood flow (rCBF) have been observed in patients with schizophrenia, even in the First episode of psychosis (FEP). However, these alterations have been associated with psychopathology inconsistently. Objectives: To analyse the relationship of the rCBF alterations, psychopathology status and emotional recognition in FEP during acute phase. Methods: We conducted a cross-sectional study on 40 patients with FEP at the acute phase of illness during their hospitalization at Zagreb University Hospital Centre. Assessment included Single-photon emission computed tomography (SPECT), Penn emotion recognition task and Positive and Negative Syndrome Scale (PANSS). Results: While our results showed hypoperfusion of rCBF in various brain regions, there was no statistically significant correlation of rCBF with emotional recognition. Correct recognition of fear was in statistically significant negative correlation with the severity of psychopathology in general and overall PANSS scales (P < 0.01). Conclusion: Emotion recognition seems to be affected by psychopathology status. However, the link of emotional recognition deficits and alterations of rCBF is still unclear.

SPECT ; emotional recognition ; first-episode psychosis

nije evidentirano