Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1033922

In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery


Jurišić Dukovski, Bisera; Bračko, Ana; Šare, Marija; Pepić, Ivan; Lovrić, Jasmina
In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery // Acta Pharmaceutica, 69 (2019), 4; 621-634 doi:10.2478/acph-2019-0054 (međunarodna recenzija, članak, znanstveni)


Naslov
In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery

Autori
Jurišić Dukovski, Bisera ; Bračko, Ana ; Šare, Marija ; Pepić, Ivan ; Lovrić, Jasmina

Izvornik
Acta Pharmaceutica (1330-0075) 69 (2019), 4; 621-634

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cationic nanoemulsions, stearylamine, ophthalmic drug delivery, biocompatibility, mucoadhesion in vitro

Sažetak
Oil-in-water nanoemulsions (NEs) represent one of the formulation approaches to improve eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is pronounced due to the electrostatic interaction of positively charged droplets with negatively charged mucins present in the tear film, providing prolonged formulation residence at the ocular surface. The aim of this study was to develop a cationic ophthalmic NE with cationic lipid stearylamine (SA) as a carrier of a positive charge. The addition of a nonionic surfactant provided the dual electro-steric stabilization of NEs and enabled tuning of SA concentration to achieve an optimal balance between its interaction with mucins and biocompatibility. Physicochemical characterization, stability profile, in vitro mucoadhesion study and biocompatibility study employing 3D HCE-T cell-based model of corneal epithelium pointed out the NE with 0.05 % (m/m) SA as the leading formulation. Minimizing SA content while retaining droplet/mucin interactions is of great importance for efficacy and safety of future ophthalmic drug products.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Jurišić Dukovski, Bisera; Bračko, Ana; Šare, Marija; Pepić, Ivan; Lovrić, Jasmina
In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery // Acta Pharmaceutica, 69 (2019), 4; 621-634 doi:10.2478/acph-2019-0054 (međunarodna recenzija, članak, znanstveni)
Jurišić Dukovski, B., Bračko, A., Šare, M., Pepić, I. & Lovrić, J. (2019) In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery. Acta Pharmaceutica, 69 (4), 621-634 doi:10.2478/acph-2019-0054.
@article{article, year = {2019}, pages = {621-634}, DOI = {10.2478/acph-2019-0054}, keywords = {cationic nanoemulsions, stearylamine, ophthalmic drug delivery, biocompatibility, mucoadhesion in vitro}, journal = {Acta Pharmaceutica}, doi = {10.2478/acph-2019-0054}, volume = {69}, number = {4}, issn = {1330-0075}, title = {In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery}, keyword = {cationic nanoemulsions, stearylamine, ophthalmic drug delivery, biocompatibility, mucoadhesion in vitro} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati