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Pregled bibliografske jedinice broj: 1033911

The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype


Lampalo, Marina; Jukić, Irena; Bingulac- Popović, Jasna; Safić, Hana; Ferara, Nikola; Popović-Grle, Sanja
The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype // Acta clinica Croatica, 57. (2018), 1.; 96-102 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1033911 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype

Autori
Lampalo, Marina ; Jukić, Irena ; Bingulac- Popović, Jasna ; Safić, Hana ; Ferara, Nikola ; Popović-Grle, Sanja

Izvornik
Acta clinica Croatica (0353-9466) 57. (2018), 1.; 96-102

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Asthma ; Hypersensitivity ; Biomarkers ; Plasminogen activator inhibitor 1 ; Polymorphism, genetic

Sažetak
Asthma is a chronic inflammatory disease that is characterized by reversible obstruction of airways, bronchial hyper-reactivity and airway remodeling. The etiology of asthma is multifactorial, with in-heritance playing an important role. The aim of our study was to investigate the importance of biomarkers of asthma and the role of plasminogen activator inhibitor-1 (PAI-1) gene as a genetic factor that could be involved in the pathogenesis of asthma. The research was conducted at Jordanovac University Department for Lung Diseases and Croatian Institute of Transfusion Medicine. The research included 149 patients with asthma and 89 healthy individuals. We collected demographic data of both study groups, determined asthma severity using GINA guidelines, and the values of biomarkers and PAI-1 by using laboratory techniques. Based on the results, we concluded that patients with allergic phenotype of asthma were younger, had better lung function and higher levels of IgE. By observing FeNO values, we were not able to distinguish asthmatic patients that had been diagnosed with obstruction of airways from asthmatic patients with normal lung function because FeNO indicates the inflammatory component of disease. The 4G/5G polymorphism of PAI-1 gene did not show any statistically significant difference in the distribution of 4G/4G, 4G/5G and 5G/5G between the group of asthmatic patients and control group

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinika za plućne bolesti "Jordanovac",
Hrvatski zavod za transfuzijsku medicinu


Citiraj ovu publikaciju

Lampalo, Marina; Jukić, Irena; Bingulac- Popović, Jasna; Safić, Hana; Ferara, Nikola; Popović-Grle, Sanja
The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype // Acta clinica Croatica, 57. (2018), 1.; 96-102 (međunarodna recenzija, članak, ostalo)
Lampalo, M., Jukić, I., Bingulac- Popović, J., Safić, H., Ferara, N. & Popović-Grle, S. (2018) The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype. Acta clinica Croatica, 57. (1.), 96-102.
@article{article, year = {2018}, pages = {96-102}, keywords = {Asthma, Hypersensitivity, Biomarkers, Plasminogen activator inhibitor 1, Polymorphism, genetic}, journal = {Acta clinica Croatica}, volume = {57.}, number = {1.}, issn = {0353-9466}, title = {The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype}, keyword = {Asthma, Hypersensitivity, Biomarkers, Plasminogen activator inhibitor 1, Polymorphism, genetic} }
@article{article, year = {2018}, pages = {96-102}, keywords = {Asthma, Hypersensitivity, Biomarkers, Plasminogen activator inhibitor 1, Polymorphism, genetic}, journal = {Acta clinica Croatica}, volume = {57.}, number = {1.}, issn = {0353-9466}, title = {The Role of Pai-1 Gene 4g/5g Polymorphism and Diagnostic Value of Biomarkers in Allergic and Non-Allergic Asthma Phenotype}, keyword = {Asthma, Hypersensitivity, Biomarkers, Plasminogen activator inhibitor 1, Polymorphism, genetic} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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