Strontium substituted biomimetic calcium phosphate system derived from cuttlefish bone (CROSBI ID 271076)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ressler, Antonia ; Cvetnić, Matija ; Antunović, Maja ; Marijanović, Inga ; Ivanković, Marica ; Ivanković, Hrvoje
engleski
Strontium substituted biomimetic calcium phosphate system derived from cuttlefish bone
Biomimetic triphasic strontium‐substituted calcium phosphate (CaP) powders were prepared by wet precipitation method at 50°C, using CaCO3, (NH2)2COH3PO4, and Sr(NO3)2 as reagents. Calcite was prepared from biogenic source (cuttlefish bone). The synthesized powders have been characterized by elemental analysis, Fourier transform infrared spectrometry, X‐ray diffraction, Rietveld refinement studies and cell viability test. Phase transformation and ion release were analyzed during 7 days of incubation in simulated body fluid at 37°C. The raw precipitated powders were composed of calcium deficient carbonated hydroxyapatite (HA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP). After heat treatment at 1200°C β‐tricalcium phosphate (β‐TCP) was detected. Strontium substitution for calcium results in an increase of lattice parameters in HA, OCP, and β‐TCP. Sr2+ occupy the Ca(1) site in HA, Ca(3, 4, 7, 8) sites in OCP and Ca(1, 2, 3, 4) sites in β‐TCP. Along with Sr2+ substitution, presence of Mg2+ and Na+ ions was detected as a result of using biogenic calcium carbonate. The culture of human embryonic kidney cells indicated noncytotoxicity of the prepared CaP powders with emphasis on the cell proliferation during 3 days of culture.
co-substitution ; hydroxyapatite ; octacalcium phosphate ; Rietveld refinement ; strontium
Glavni autor: Antonia Ressler
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Podaci o izdanju
108 (4)
2020.
1697-1709
objavljeno
1552-4973
1552-4981
10.1002/jbm.b.34515
Povezanost rada
Biologija, Kemijsko inženjerstvo, Temeljne tehničke znanosti