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Pregled bibliografske jedinice broj: 1033167

Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study


Karin-Kujundzić, Valentina; Kardum, Vedran; Šola, Ida Marija; Škrtić, Anita; Paić, Frane; Skenderi, Faruk; Šerman, Alan; Nikuševa-Martić, Tamara; Vranić, Semir; Šerman, Ljiljana
Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study // Apmis, 128 (2020), 3; 201-210 doi:10.1111/apm.13012 (međunarodna recenzija, članak, znanstveni)


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Naslov
Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study

Autori
Karin-Kujundzić, Valentina ; Kardum, Vedran ; Šola, Ida Marija ; Škrtić, Anita ; Paić, Frane ; Skenderi, Faruk ; Šerman, Alan ; Nikuševa-Martić, Tamara ; Vranić, Semir ; Šerman, Ljiljana

Izvornik
Apmis (0903-4641) 128 (2020), 3; 201-210

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ovary ; Serous carcinoma ; Dishevelled proteins ; Ovarian carcinoma cell lines ; Wnt signaling pathway
(ovary ; serous carcinoma ; Dishevelled proteins ; ovarian carcinoma cell lines ; Wnt signaling pathway)

Sažetak
Dishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation and invasion, its increased activation is associated with cancer development as well. To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8 and OVSAHO. DVL protein expression in serous ovarian carcinomas tissues was analyzed using immunohistochemistry while DVL protein and mRNA expressions in HGSC cell lines were analyzed using western blot and quantitative real-time PCR. DVL1 protein expression was significantly higher in LGSC compared with normal ovarian tissue, while DVL3 was overexpressed in both LGSC and HGSC. DVL2 and DVL3 protein expression was higher in HGSC cell lines when compared with normal control cell line while DVL1, DVL2, and DVL3 mRNA expression was significantly increased only in OVSAHO cell line. Survival analysis revealed no significant impact of DVL proteins on patients’ outcome. Our data show an active involvement of Dishevelled family proteins in serous ovarian carcinomas. Further studies should confirm the clinical relevance of these observations.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh",
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com doi.org

Citiraj ovu publikaciju:

Karin-Kujundzić, Valentina; Kardum, Vedran; Šola, Ida Marija; Škrtić, Anita; Paić, Frane; Skenderi, Faruk; Šerman, Alan; Nikuševa-Martić, Tamara; Vranić, Semir; Šerman, Ljiljana
Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study // Apmis, 128 (2020), 3; 201-210 doi:10.1111/apm.13012 (međunarodna recenzija, članak, znanstveni)
Karin-Kujundzić, V., Kardum, V., Šola, I., Škrtić, A., Paić, F., Skenderi, F., Šerman, A., Nikuševa-Martić, T., Vranić, S. & Šerman, L. (2020) Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study. Apmis, 128 (3), 201-210 doi:10.1111/apm.13012.
@article{article, author = {Karin-Kujundzi\'{c}, Valentina and Kardum, Vedran and \v{S}ola, Ida Marija and \v{S}krti\'{c}, Anita and Pai\'{c}, Frane and Skenderi, Faruk and \v{S}erman, Alan and Niku\v{s}eva-Marti\'{c}, Tamara and Vrani\'{c}, Semir and \v{S}erman, Ljiljana}, year = {2020}, pages = {201-210}, DOI = {10.1111/apm.13012}, keywords = {Ovary, Serous carcinoma, Dishevelled proteins, Ovarian carcinoma cell lines, Wnt signaling pathway}, journal = {Apmis}, doi = {10.1111/apm.13012}, volume = {128}, number = {3}, issn = {0903-4641}, title = {Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study}, keyword = {Ovary, Serous carcinoma, Dishevelled proteins, Ovarian carcinoma cell lines, Wnt signaling pathway} }
@article{article, author = {Karin-Kujundzi\'{c}, Valentina and Kardum, Vedran and \v{S}ola, Ida Marija and \v{S}krti\'{c}, Anita and Pai\'{c}, Frane and Skenderi, Faruk and \v{S}erman, Alan and Niku\v{s}eva-Marti\'{c}, Tamara and Vrani\'{c}, Semir and \v{S}erman, Ljiljana}, year = {2020}, pages = {201-210}, DOI = {10.1111/apm.13012}, keywords = {ovary, serous carcinoma, Dishevelled proteins, ovarian carcinoma cell lines, Wnt signaling pathway}, journal = {Apmis}, doi = {10.1111/apm.13012}, volume = {128}, number = {3}, issn = {0903-4641}, title = {Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study}, keyword = {ovary, serous carcinoma, Dishevelled proteins, ovarian carcinoma cell lines, Wnt signaling pathway} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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