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Pregled bibliografske jedinice broj: 1032835

Direct Assembly and Metal-Ion Binding Properties of Oxytocin Monolayer on Gold Surfaces


Mervinetsky, Evgeniy; Alshanski, Israel; Buchwald, Jörg; Dianat, Arezoo; Lončarić, Ivor; Lazić, Predrag; Crljen, Željko; Gutierrez, Rafael; Cuniberti, Gianaurelio; Hurevich, Mattan; Yitzchaik, Shlomo
Direct Assembly and Metal-Ion Binding Properties of Oxytocin Monolayer on Gold Surfaces // Langmuir, 35 (2019), 34; 11114-11122 doi:10.1021/acs.langmuir.9b01830 (međunarodna recenzija, članak, znanstveni)


Naslov
Direct Assembly and Metal-Ion Binding Properties of Oxytocin Monolayer on Gold Surfaces

Autori
Mervinetsky, Evgeniy ; Alshanski, Israel ; Buchwald, Jörg ; Dianat, Arezoo ; Lončarić, Ivor ; Lazić, Predrag ; Crljen, Željko ; Gutierrez, Rafael ; Cuniberti, Gianaurelio ; Hurevich, Mattan ; Yitzchaik, Shlomo

Izvornik
Langmuir (0743-7463) 35 (2019), 34; 11114-11122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Density functional theory ; biosensors

Sažetak
Peptides are very common recognition entities that are usually attached to surfaces using multistep processes. These processes require modification of the native peptides and of the substrates. Using functional groups in native peptides for their assembly on surfaces without affecting their biological activity can facilitate the preparation of biosensors. Herein, we present a simple single-step formation of native oxytocin monolayer on gold surface. These surfaces were characterized by atomic force spectroscopy, spectroscopic ellipsometry, and X- ray photoelectron spectroscopy. We took advantage of the native disulfide bridge of the oxytocin for anchoring the peptide to the Au surface, while preserving the metal-ion binding properties. Self-assembled oxytocin monolayer was used by electrochemical impedance spectroscopy for metal-ion sensing leading to subnanomolar sensitivities for zinc or copper ions.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekt / tema
EK-H2020-664786 (EK - H2020-FETOPEN-2014-2015-RIA)

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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