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Synthesis of acetylsalicylic acid in choline chloride based eutectic solvents

Acetylsalicylic acid or aspirin is a medicine that has antipyretic and anticoagulant properties and acts by inhibiting activity of the enzyme cyclooxygenase which is responsible for the production of prostaglandins, substances responsible for inflammation and pain. The most known method of aspirin synthesis is acetylation of salicylic acid with acetic anhydride in acidic medium, phosphoric or sulfuric acid. The aim of this research was to investigate the possibility of aspirin synthesis with the use of choline chloride based (ChCl) eutectic solvents for which a catalytic role in the acetylation reaction can be assumed. The results of the experimental work showed that the eutectic solvents ChCl: levulinic acid and ChCl: citric acid can’t be used as solvent/catalyst for the acetylsalicylic acid synthesis. However, with the use of eutectic solvent ChCl: urea, acetylsalicylic acid was obtained in relatively high yield (55 %) and for the first time the possibility of using eutectic solvent in the acetylsalicylic acid synthesis was confirmed.

Aspirin ; acetylsalicylic acid ; eutectic solvents ; synthesis ; choline chloride

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