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Pregled bibliografske jedinice broj: 1032215

INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY


Rojnić Kuzman, Martina; Makarić, Porin; Bošnjak Kuharić, Dina; Kekin, Ivana; Rossini Gajšak, Linda; Boban, Marina; Božina, Nada; Božina, Tamara; Ćelić Ružić, Mirela; Darmopil, Sanja et al.
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY // Psychiatria Danubina, 31 (2019), 2; 162-171 doi:10.24869/psyd.2019.162 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1032215 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY

Autori
Rojnić Kuzman, Martina ; Makarić, Porin ; Bošnjak Kuharić, Dina ; Kekin, Ivana ; Rossini Gajšak, Linda ; Boban, Marina ; Božina, Nada ; Božina, Tamara ; Ćelić Ružić, Mirela ; Darmopil, Sanja ; Filipčić, Igor ; Ganoci, Lana ; Hladnik, Ana ; Madžarac, Zoran ; Malojčić, Branko ; Mihaljević Peleš, Alma ; J. Mueller, Daniel ; Ostojić, Draženka ; Petanjek, Zdravko ; Petrović, Ratimir ; Vogrinc, Željka ; Savić, Aleksandar ; Silić, Ante ; Šagud, Marina ; Živković, Maja ; Bajić, Žarko

Izvornik
Psychiatria Danubina (0353-5053) 31 (2019), 2; 162-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia ; first episode psychosis ; biological markers ; neurocognition ; TCD ; SPECT ; stress ; cortisole

Sažetak
In this project, we recruited a sample of 150 patients with first episode of psychosis with schizophrenia features (FEP) and 100 healthy controls. We assessed the differences between these two groups, as well as the changes between the acute phase of illness and subsequent remission among patients over 18- month longitudinal follow-up. The assessments were divided into four work packages (WP): WP1- psychopathological status, neurocognitive functioning and emotional recognition ; WP2- stress response measured by saliva cortisol during a stress paradigm ; cerebral blood perfusion in the resting state (with single photon emission computed tomography (SPECT) and during activation paradigm (with Transcranial Ultrasonography Doppler (TCD) ; WP3-post mortem analysis in histologically prepared human cortical tissue of post mortem samples of subjects with schizophrenia in the region that synaptic alteration was suggested by WP1 and WP2 ; WP4- pharmacogenetic analysis (single gene polymorphisms and genome wide association study (GWAS). We expect that the analysis of these data will identify a set of markers that differentiate healthy controls from patients with FEP, and serve as an additional diagnostic tool in the first episode of psychosis, and prediction tool which can be then used to help tailoring individualized treatment options. In this paper, we describe the project protocol including aims and methods and provide a brief description of planned post mortem studies and pharmacogenetic analysis

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
UIP-2014-09-1245

Ustanove
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Psihijatrijska bolnica "Sveti Ivan" Zagreb,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Citiraj ovu publikaciju

Rojnić Kuzman, Martina; Makarić, Porin; Bošnjak Kuharić, Dina; Kekin, Ivana; Rossini Gajšak, Linda; Boban, Marina; Božina, Nada; Božina, Tamara; Ćelić Ružić, Mirela; Darmopil, Sanja et al.
INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY // Psychiatria Danubina, 31 (2019), 2; 162-171 doi:10.24869/psyd.2019.162 (međunarodna recenzija, članak, znanstveni)
Rojnić Kuzman, M., Makarić, P., Bošnjak Kuharić, D., Kekin, I., Rossini Gajšak, L., Boban, M., Božina, N., Božina, T., Ćelić Ružić, M. & Darmopil, S. (2019) INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY. Psychiatria Danubina, 31 (2), 162-171 doi:10.24869/psyd.2019.162.
@article{article, year = {2019}, pages = {162-171}, DOI = {10.24869/psyd.2019.162}, keywords = {schizophrenia, first episode psychosis, biological markers, neurocognition, TCD, SPECT, stress, cortisole}, journal = {Psychiatria Danubina}, doi = {10.24869/psyd.2019.162}, volume = {31}, number = {2}, issn = {0353-5053}, title = {INTEGRATION OF COMPLEMENTARY BIOMARKERS IN PATIENTS WITH FIRST EPISODE PSYCHOSIS: RESEARCH PROTOCOL OF A PROSPECTIVE FOLLOW UP STUDY}, keyword = {schizophrenia, first episode psychosis, biological markers, neurocognition, TCD, SPECT, stress, cortisole} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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