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Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era? (CROSBI ID 270859)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Rončević, Tomislav ; Puizina, Jasna ; Tossi, Alessandro Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era? // International journal of molecular sciences, 20 (2019), 22; 5713, 32. doi: 10.3390/ijms20225713

Podaci o odgovornosti

Rončević, Tomislav ; Puizina, Jasna ; Tossi, Alessandro

engleski

Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era?

Resistance to antibiotics is one of the main current threats to human health and every year multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a result. Ever since their discovery, some 40 years ago, the antimicrobial peptides (AMPs) of innate defense have been hailed as a potential alternative to conventional antibiotics due to their relatively low potential to elicit resistance. Despite continued effort by both academia and start-ups, currently there are still no antibiotics based on AMPs in use. In this study, we discuss what we know and what we do not know about these agents, and what we need to know to successfully translate discovery to application. Understanding the complex mechanics of action of these peptides is the main prerequisite for identifying and/or designing or redesigning novel molecules with potent biological activity. However, other aspects also need to be well elucidated, i.e., the (bio)synthetic processes, physiological and pathological contexts of their activity, and a quantitative understanding of how physico-chemical properties affect activity. Research groups worldwide are using biological, biophysical, and algorithmic techniques to develop models aimed at designing molecules with the necessary blend of antimicrobial potency and low toxicity. Shedding light on some open questions may contribute toward improving this process.

antimicrobial peptides ; antimicrobial resistance ; AMP identification and design ; biosynthesis ; mode of action ; physico-chemical properties ; therapeutic potential

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Podaci o izdanju

20 (22)

2019.

5713

32

objavljeno

1422-0067

10.3390/ijms20225713

Trošak objave rada u otvorenom pristupu

Povezanost rada

Biologija, Biotehnologija, Interdisciplinarne prirodne znanosti

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