hrvatski

Nanostructured composite materials based on self-assembled peptide hydrogelator Ac-L-Phe-L- Phe-L-Ala-NH2 and embedded liposomes

The properties of a material depend both on the nature of its constituents and the interactions between them.1 These interactions and the recognition processes that they underlie allow the design of materials and the control of their build-up from suitable units by self- organization.2, 3 Design and synthesis of self- assembled nanomaterials with diversified structures and functionalities via fine tuning of supramolecular building blocks increased rapidly.4 Self-assembling peptides have been widely recognized as nanomaterials with high potential for an extensive range of biomedical applications from drug delivery to tissue engineering, owing to their hydrophilic character and biocompatibility.5, 6 The aim of the present study was the preparation and characterization of functional supramolecular systems based on peptide hydrogelator Ac-L-Phe- L-Phe-L-Ala-NH2 and liposomes with incorporated model proteins. The gelling properties and composite self-assembly of the hydrogelator Ac- L-Phe-L-Phe-L-Ala-NH2 with the addition of liposomes and proteins were studied by spectroscopy and morphology of composite by microscopy.

Nano-composite materials ; Self-assembly ; Hydrogelator ; Liposomes

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