engleski

Synthesis, characterization and self-assembly of small peptidic gelators based on amyloid β-protein

Alzheimer's disease is characterized by the extracellular fibrillar deposits of the 39-42 amino acid amyloid-β proteins (Aβ). It was shown that the KLVFF fragment of Aβ- peptide is responsible for the formation of amyloid fibrils. The self-assembly phenomena of the low molecular weight peptides into supramolecular gels show resemblance to amyloid-β protein aggregation and hence may serve as a simple model for A β- aggregation. The series of tripeptide gelators incorporating amino acids sequence present in the Aβ-protein denoted responsible for the protein aggregation have been synthesized and characterized. Tripeptide derivative Ac-FFA-NH2 was capable to self-assemble into hydrogel network at physiological pH. The obtained hydrogel successfully mimics the extracellular matrix and was proved to serve as stable and biocompatible physical support in improving HEK293T cells biological outcome in vitro.

Self-assembly ; Small peptidic gelators ; Amyloid β-protein

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