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Pregled bibliografske jedinice broj: 1032095

Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity


Zlatić, Katarina; Uzelac, Lidija; Kralj, Marijeta; Basarić, Nikola
Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity // 3rd mini symposium of medicinal and pharmaceutical section / Fidelta d.o.o., Zagreb
Fidelta d.o.o., Zagreb, Hrvatska, 2019. str. 8-8 (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1032095 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity

Autori
Zlatić, Katarina ; Uzelac, Lidija ; Kralj, Marijeta ; Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd mini symposium of medicinal and pharmaceutical section / Fidelta d.o.o., Zagreb / - , 2019, 8-8

Skup
3rd mini symposium of medicinal and pharmaceutical section

Mjesto i datum
Fidelta d.o.o., Zagreb, Hrvatska, 12.11.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
photochemistry ; quinone methide ; BODIPY

Sažetak
Quinone methides (QM) are reactive intermediers that can be generated in photochemical reactions, such as photodeamination.1-4 QMs exhibit biological activity, which is related to their ability to react in Michael addition reactions with various amines and sulfides, including amino acids and nucleotides.5-6 Reaction with nucleotides induce DNA alkylation and cross-linking, and consequently, cytotoxicity.7-9 Photochemical generation of QMs under mild conditions and citotoxic biological activity make QM precursor molecules potential photoactivable anticancer drugs. We incorporated QM precursor units into BODIPY chromophore to obtain molecules with desired photochemical properties which can be excited by visible light.10 BODIPY derivates are commonly used as dyes for biomolecular labeling since they are characterized by good photochemical stability and excellent photophysical and spectral properties.11 Several BODIPY-QM precursor molecules have been synthesized and their photophisical properties and photochemical reactivity were investigated. The experimental observations were backed up by TD-DFT calculations. Non-covalent interactions of BODIPY-QM precursors with biomacromolecules and the ability of photochemically formed QMs to alkylate biomacromolecules were demonstrated by photonduced fluorescent labeling of bovine serum albumin.12 Furthermore, antiproliferative activity of synthesized BODIPY-QM precursors was investigated using MTT assay on several human cancer cell lines with and without irradiation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ - 2013-11) ( POIROT)
HRZZ-IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (SupraPhotoE) (Basarić, Nikola, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Lidija Uzelac (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Katarina Zlatić (autor)

Avatar Url Nikola Basarić (autor)

Citiraj ovu publikaciju

Zlatić, Katarina; Uzelac, Lidija; Kralj, Marijeta; Basarić, Nikola
Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity // 3rd mini symposium of medicinal and pharmaceutical section / Fidelta d.o.o., Zagreb
Fidelta d.o.o., Zagreb, Hrvatska, 2019. str. 8-8 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Zlatić, K., Uzelac, L., Kralj, M. & Basarić, N. (2019) Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity. U: 3rd mini symposium of medicinal and pharmaceutical section / Fidelta d.o.o., Zagreb.
@article{article, year = {2019}, pages = {8-8}, keywords = {photochemistry, quinone methide, BODIPY}, title = {Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity}, keyword = {photochemistry, quinone methide, BODIPY}, publisherplace = {Fidelta d.o.o., Zagreb, Hrvatska} }
@article{article, year = {2019}, pages = {8-8}, keywords = {photochemistry, quinone methide, BODIPY}, title = {Quinone Methide Precursors with BODIPY Chromophore: Synthesis, Photochemistry and Biological Activity}, keyword = {photochemistry, quinone methide, BODIPY}, publisherplace = {Fidelta d.o.o., Zagreb, Hrvatska} }




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