engleski

First case of transmitted drug resistance to HIV Integrase-strand Transfer Inhibitors in Croatia. 2nd Sout-East European Conference on Travel, Tropical, Migration Medicine & HIV, Dubrovnika, Croatia.

Croatia has a centralized system of HIV clinical care and all patients are treated at University Hospital for Infectious Diseases “Dr. Fran Mihaljevic”, Zagreb (UHID). Previous national study showed a high prevalence of transmitted drug resistance (TDR) of 21.6% (in the period 2006 to 2008) (1). The study analyzed primary resistance to reverse transcriptase (RTI) and protease inhibitors (PI). Our recent study confirmed that TDR is still very high in Croatia (23.4%, analysed for the time period 2014-2015) (2). Analysis of primary resistance to integrase strand transfer inhibitors (INSTI) has not yet been examined in Croatia, however during 2016-2017 there were 3 clinical cases of INSTI resistance among INSTI-treated HIV-1 patients. With the appearance of first clinical cases that confer resistance to INSTI, there is a possibility for circulation of INSTI-resistant HIV-1 among newly diagnosed HIV-1 patients. Therefore, in this study the prevalence of TDR to INSTI was examined in a cohort of newly diagnosed HIV-1 patients from Croatia.

HIV-1, primarna rezistencija na inhibitore integraze

nije evidentirano