engleski

High prevalence of Transmitted HIV Drug Resistance Mutations in a cohort of newly diagnosed HIV-infected patients at entrance to care in the period from 2014 to 2016: the Croatian data

Croatia has a centralized system of HIV-1 care and all patients are treated at University Hospital for Infectious Diseases “Dr.Fran Mihaljević”. HIV drug- resistance testing is routinely performed for all patients experiencing virological failure and for selected therapy-naive patients. Results of our previous national study showed substantially higher prevalence of transmitted drug resistance mutations(TDRM)of 21.6%(in the period 2006 to 2008, compared with European data, with the prevalence of 8.4%(in the period 2002-2005.Moreover, the study by Grgic et al. determined the highest risk factor for HIV transmission in the group of men who have sex with men(MSM(80/118 patients, 67.8%), who accounted for 76.9% of all transmitted drug resistance cases.Since the acute/recent phase of infection represents the most opportune time to detect transmitted drug resistance(TDR, the goal of the study was to determine the prevalence of TDRM in therapy-naive patients with recently acquired HIV infection, who entered clinical care at our center in the period 2014-2016. Additionally, the evolutionary relationship between nucleotide sequences of patients who carried T215S primary resistance mutation and their possible interconnection with the local T215S transmission cluster was assessed.

HIV-1, primary drug resistance

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