engleski

Effects of topical Hypericum perforatum treatment on wound healing in chemical and mechanical skin damage models

Introduction: Hypericum perforatum topical preparations are used in traditional medicine for the treatment of wounds, abrasions and burns. Their use in those indications could be justified with Hypericums’ anti-inflammatory, antimicrobial and astringent effects, as well as its stimulating effects on tissue growth and keratinocyte differentiation. Further, several clinical trials had shown its potential in wound healing. The aim of the study was to determine the effectiveness of ointment containing 20% Hypericum perforatum oil on promoting skin recovery in different human skin damage models on healthy volunteers. Materials and methods: Skin damage was induced on four sites on volunteers’ forearms (N = 28). Two sites were irritated chemically using sodium laurylsulphate under 24-hour occlusion. The stratum corneum on the other two sites were removed by tape-stripping to induce mechanical damage. Two damaged skin areas were treated with Hypericum ointment while the remaining were treated with placebo for nine days. Skin recovery were assessed measuring skins’ transepidermal water loss, hydration and erythema values. Results: Induced skin damage lead to symmetrical increase in measured parameters in comparison to baseline in both tested models. Treatment with Hypericum oil improved skin parameters in comparison to their values after irritation in both models. However, there were no differences in outcomes when compared with placebo treatment in either model. Conclusions: Tested Hypericum ointment in used dose did not improve skin recovery in chemical and mechanical skin damage models.

Hypericum perforatum ; human in vivo skin damage models ; tape-stripping ; sodium laurylsulphate

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