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SPINDLE EPITHELIAL TUMOR WITH THYMUS-LIKE ELEMENTS (SETTLE): A Case Report (CROSBI ID 683502)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Lozić, Alex Anton ; Mateša, Neven ; Besser Silconi, Žana ; Labinac Peteh, Loredana ; Peruško Kozina, Petra ; Mićić, Tamara ; Primc, Claudio ; Mustać, Elvira SPINDLE EPITHELIAL TUMOR WITH THYMUS-LIKE ELEMENTS (SETTLE): A Case Report // Abstract book of the 42nd European Congress of Cytology 2019. 2019. str. 48-48

Podaci o odgovornosti

Lozić, Alex Anton ; Mateša, Neven ; Besser Silconi, Žana ; Labinac Peteh, Loredana ; Peruško Kozina, Petra ; Mićić, Tamara ; Primc, Claudio ; Mustać, Elvira

engleski

SPINDLE EPITHELIAL TUMOR WITH THYMUS-LIKE ELEMENTS (SETTLE): A Case Report

Spindle epithelial tumor with thymus-like elements is a rare, biphasic and initially indolent tumor of thyroid with a low malignant potential in young patients (median age 18 yrs). Delayed metastases can occur in lymph nodes, mediastinum, vertebrae or lungs even many years after the initial diagnosis. There are less than 50 cases reported in the literature and few reported metastases. The cytologic descriptions of SETTLE are rare and tend to focus on a hypercelular biphasic appearance. Macroscopic description is a well-circumsribed encapsulated or infiltrative tumor with white tan cut surface separated by sclerotic stroma. Microscopically, it has a biphasic pattern made by spindle cells and epithelial structures (cords, tubules, papillae or glandular appearance, but there are also rare monomorfic variants which have spindle or glandular appearance only. There are no or rare lymphocytes, mitotic activity and necrosis. SETTLE may have a good prognosis if appropriately treated at the initial presentation and if a patient undergo long-term monitoring with a regular clinical and morphological evaluation. The golden standard is surgery and in advanced stages of disease also chemotherapy and radiotherapy. We report findings in a 17 years old girl through ultrasound and cytologic findings, surgical procedures and histopatological findings . After finding a small, hypoechogenic node only 5 mm in diameter on ultrasound examine by a specialist of nuclear medicine, we made a fine needle aspiration biopsy. The node was interpreted morphologically by a cytologist as “probably SETTLE“ although the basic immunocytochemistry was partially done. The patient underwent a recommended left lobectomy of the thyroid and the diagnosis was confirmed by pathologist (morphology and immunohistochemistry). The follow-up ultrasound almost 4 years later revealed no local recurrence or metastatic disease.

Tumor of the thyroid, Cytology, Spindle epithelial tumor with thymus-like elements, SETTLE of the thyroid

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Podaci o prilogu

48-48.

2019.

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objavljeno

Podaci o matičnoj publikaciji

Abstract book of the 42nd European Congress of Cytology 2019

Podaci o skupu

European Control Conference (ECC2019)

pozvano predavanje

16.06.2019-19.06.2019

Malmö, Švedska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti