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Pregled bibliografske jedinice broj: 1030959

Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature


Anic, Branimir; Padjen, Ivan; Mayer, Miroslav; Bosnić, Dubravka; Cerovec, Mislav
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature // Acta Dermatovenerologica Croatica, 22 (2014), 180-188 (recenziran, članak, znanstveni)


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Naslov
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature

Autori
Anic, Branimir ; Padjen, Ivan ; Mayer, Miroslav ; Bosnić, Dubravka ; Cerovec, Mislav

Izvornik
Acta Dermatovenerologica Croatica (1330-027X) 22 (2014); 180-188

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spondyloarthropathies, acquired hyperostosis syndrome, psoriasis, therapeutics

Sažetak
Although the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome was defined as a distinct entity more than 20 years ago, its classification within the spectrum of inflammatory rheumatic diseases and the proper therapeutic approach are still a matter of debate. We present four patients diagnosed with the SAPHO syndrome treated and followed-up in our Department, demonstrating the diversity of their clinical courses and their responses to different therapeutic approaches. We also review the clinical, laboratory, and imaging features of the SAPHO syndrome described in the relevant literature. Despite the growing quantity of published data on the clinical features of the syndrome and the recognition of two disease patterns (inflammatory and bone remodeling disease), it is still not clear whether these possible disease subsets require different therapeutic strategies. Tumor necrosis factor- alpha (TNF-α) inhibitors have been suggested to be effective in patients with the inflammatory pattern, whereas bisphosphonates seem to be effective in patients with bone remodeling disease ; however, this is still a hypothesis not yet confirmed by adequately designed clinical studies. Further research is needed to assess disease features predicting favorable response to the two therapeutic modalities beyond the first line of therapy – TNF-α inhibitors and bisphosphonates.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Profili:

Avatar Url Ivan Padjen (autor)

Avatar Url Miroslav Mayer (autor)

Avatar Url Mislav Cerovec (autor)

Avatar Url Branimir Anić (autor)

Poveznice na cjeloviti tekst rada:

adc.mef.hr

Citiraj ovu publikaciju:

Anic, Branimir; Padjen, Ivan; Mayer, Miroslav; Bosnić, Dubravka; Cerovec, Mislav
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature // Acta Dermatovenerologica Croatica, 22 (2014), 180-188 (recenziran, članak, znanstveni)
Anic, B., Padjen, I., Mayer, M., Bosnić, D. & Cerovec, M. (2014) Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. Acta Dermatovenerologica Croatica, 22, 180-188.
@article{article, year = {2014}, pages = {180-188}, keywords = {spondyloarthropathies, acquired hyperostosis syndrome, psoriasis, therapeutics}, journal = {Acta Dermatovenerologica Croatica}, volume = {22}, issn = {1330-027X}, title = {Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature}, keyword = {spondyloarthropathies, acquired hyperostosis syndrome, psoriasis, therapeutics} }
@article{article, year = {2014}, pages = {180-188}, keywords = {spondyloarthropathies, acquired hyperostosis syndrome, psoriasis, therapeutics}, journal = {Acta Dermatovenerologica Croatica}, volume = {22}, issn = {1330-027X}, title = {Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature}, keyword = {spondyloarthropathies, acquired hyperostosis syndrome, psoriasis, therapeutics} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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