engleski

Morphological properties of the epithelial tissue

Knowing the morphology of an epithelial tissue is im- portant due to understanding proceses like growth and development of the tissue, wound healing and pro- gression of the cancer. We study the structure of the MDCK II epithelial cells in circular colonies. Cell nu- clei can be approximated with ellipses and the Voronoi tesselation generated by those ellipses coincides well with the cell membranes. We compare the tissue cells to the Voronoi cells generated by randomly packed el- lipses obtained from the cell nuclei. The comparison is done by studying the probability distributions of cho- sen morphological measures calculated from the cells. We find that randomly packed ellipses reproduce the morphology of the tissue well at the low cell density. At high cell density we observe more regular structure of the tissue an we see the deviations of the random model from the cell tissue.

epithelial tissue ; morphological measures ; packing ; ellipses

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