engleski

Morphological properties of the epithelial tissue

Knowing the morphology of an epithelial tissue is important due to understanding processes like growth and development of the tissue, wound healing and progression of the cancer. We study the structure of the MDCK II epithelial cells in circular colonies. Cell nuclei can be approximated with ellipses and the Voronoi tessellation generated by those ellipses coincides well with the cell membranes. We compare the tissue cells to the Voronoi cells generated by randomly packed ellipses obtained from the cell nuclei. The comparison is done by studying the probability distributions of chosen morphological measures calculated from the cells. We find that randomly packed ellipses reproduce the morphology of the tissue well at the low cell density. At high cell density we observe more regular structure of the tissue and we see the deviations of the random model from the cell tissue.

epithelial tissue ; morphological measures

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