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An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives


Ismaili, Hamit; Ban, Željka; Matić, Josipa; Saftić, Dijana; Jukić, Marijana; Glavaš-Obrovac, Ljubica; Žinić, Biserka
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives // Croatica chemica acta (2019) doi:10.5562/cca3567 (znanstveni, prihvaćen)


Naslov
An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives

Autori
Ismaili, Hamit ; Ban, Željka ; Matić, Josipa ; Saftić, Dijana ; Jukić, Marijana ; Glavaš-Obrovac, Ljubica ; Žinić, Biserka

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Croatica chemica acta (2019)

Status rada
Prihvaćen

Ključne riječi
5-aminouracil ; arylsulfonyl chlorides ; 5-aminosulfonyl uracil derivatives ; in vitro ; anticancer activity

Sažetak
Abstract: Efficient synthesis of 5-aminosulfonyl uracil derivatives 2−9 and results of their antiproliferative activity are provided. Sulfonylation of the amino group in 5-aminouracil 1 with selected arylsulfonyl chlorides occurs regioselectively when the reaction is carried out in pyridine at room temperature. Simple isolation of the products by recrystallization of the crude product mixture from aqueous methanol provides good to excellent yields. The prepared 5-aminosulfonyl uracil derivatives 2−9 were tested for the antiproliferative activity on a panel of seven tumor cell lines of different histological origin (HeLa, Caco-2, NCI-H358, Raji, HuT78, Jurkat, K562) and normal MDCK I cells. Derivatives 2−9 were found more efficient to lymphoma and leukemia cells compared to solid tumor and normal cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2935 - Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida (Biserka Žinić, )
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Ljubica Glavaš Obrovac, )
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )
VIF2017-MEFOS-8

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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