engleski

GHB roller-coaster: seroronin syndrome and withdrawal

Here, we present the first case (to our knowledge) of serotonin syndrome following intoxication of GHB. Our aim was to describe this specific clinical presentation and investigate possible mechanisms leading to it. This case is unique as it is the first to describe the development of serotonin syndrome after GHB-intoxi-cation. Considering the polydrug misuse and the comor-bid psychiatric conditions in GHB users, in addition to the rising prevalence of GHB use, one must bare in mind the array of possible pharmacological interactions and clinical presentations that can be seen in both GHB intoxication and withdrawal. Although GHB-intoxica-tion could lead to a variety of severe complications, GHB is still not a part of the routine toxicology testing. This, in addition to the observation that serotonin syndrome is frequently unrecognized condition, can result in a prolongation of time for reaching the right diagnosis and starting the adequate treatment in emer-gency cases where the time is usually lacking. There-fore, when GHB-intoxication is suspected, clinicians should be aware of all possible life-threatening diffe-rential diagnosis, including serotonin syndrome, to provide adequate and immediate care and to avoid possible fatal outcome.

GHB ; serotonin ; serotonin syndrome ; serotonin withdrawal

nije evidentirano