engleski

Bivalent and Trivalent Transition Metal Complexes of Azo Compounds Derived from Anthraquinone and Their Mutagenic-Teratogenic Effects

4-(5′-aminonaphtalene-3′-sulfonic acid)azo-(2″- N-(4′″, 6′″-dichloro-S-triazine) benzene-5″-(β- sulfatoethyl sulfonyl)-2-methyl anthraquinone (2a), 4-(2′-aminobenzenesulfonic acid)azo-(2″- N-(4′″, 6′″-dichloro-S-triazine)-3″- benzensulfonic acid)-2-methyl anthraquinone, 4- (5′-aminonaphtalene-3′-sulfonic acid)azo-(2″-N- (4′″, 6′″-dichloro- S-triazine)benzen-5″-(β- sulfatoethyl sulfonyl)-2-methyl anthraquinone and 4-(p-(β-sulfatoethyl sulfonyl) azo-(2″-N- (4′″, 6′″ -dichloro-S-triazine) naphtalene-5′ sulfonic acid)-2-methyl anthraquinone with Fe111, Co11 metal complexes were prepared and used for determination of mutagenic and teratogenic effects in Ames/Salmonella/Microsome Test and in embryos of rats. 2a-Fe and 2a-Co were not mutagenic for both TA98 and TA100 strains with and without metabolic activator S9mix.

Anthraquinone ; Azo, Metal Complex ; Mutagenicity ; Teratogenicity

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