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Impact of the 2014 NIH chronic graft-versus- host disease scoring criteria modifications assessed in a large cohort of severely affected patients (CROSBI ID 270269)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kerep, Ana Zelic ; Broome, Jacob ; Pirsl, Filip ; Curtis, Lauren M. ; Steinberg, Seth M. ; Mitchell, Sandra A. ; Cowen, Edward W. ; Pichard, Dominique C. ; Joe, Galen O. ; Comis, Leora E. et al. Impact of the 2014 NIH chronic graft-versus- host disease scoring criteria modifications assessed in a large cohort of severely affected patients // Bone marrow transplantation (Basingstoke), 54 (2018), 1; 76-84. doi: 10.1038/s41409-018-0224-3

Podaci o odgovornosti

Kerep, Ana Zelic ; Broome, Jacob ; Pirsl, Filip ; Curtis, Lauren M. ; Steinberg, Seth M. ; Mitchell, Sandra A. ; Cowen, Edward W. ; Pichard, Dominique C. ; Joe, Galen O. ; Comis, Leora E. ; Mays, Jacqueline W. ; Datiles, Manuel B. ; Stratton, Pamela ; Zolton, Jessica ; Berger, Ann ; Hendricks, Jennifer ; Kenyon, Megan ; Baruffaldi, Judy ; Titarenko, Irina ; Pulanic, Drazen ; Baird, Kristin ; Fowler, Daniel H. ; Gress, Ronald E. ; Pavletic, Steven Z.

engleski

Impact of the 2014 NIH chronic graft-versus- host disease scoring criteria modifications assessed in a large cohort of severely affected patients

In 2005, the National Institutes of Health (NIH) chronic graft-versus-host disease (cGVHD) consensus project provided diagnosis and staging criteria, based mostly on clinical experience and expert opinion. These criteria were revised in 2014, aiming to provide enhanced specificity and clarity. However, the impact of 2014 changes to the original NIH cGVHD severity scoring criteria has not been reported. In this study, 284 patients, prospectively enrolled on the National Cancer Institute's cross-sectional cGVHD natural history study, were scored using the 2005 NIH cGVHD criteria and then rescored according to the 2014 modifications. In comparing the two criteria, 2014 cGVHD global severity scoring resulted in a tendency toward being categorized as milder scores (75 vs. 72% of severe score per 2014, p = 0.0009), with a statistically significant shift in NIH liver and lung scores toward milder categories (p < 0.0001). 2005 and 2014 NIH global severity scores showed a significant association with reduced grip strength (p < 0.0001), reduced joint range of motion (p = 0.0003), and the subspecialist evaluation score (p < 0.0001). Poor survival prediction of the severe NIH lung score is also retained in the new criteria (p = 0.0012). These findings support the use of 2014 cGVHD scoring criteria in continuous efforts to develop better classification systems.

chronic graft versus host disease ; criteria comparison

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Podaci o izdanju

54 (1)

2018.

76-84

objavljeno

0268-3369

1476-5365

10.1038/s41409-018-0224-3

Povezanost rada

Kliničke medicinske znanosti

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