engleski

CHEMICAL COMPOSITION OF CLINOPODIUM VULGARE L. EXTRACTS AND THEIR ANTIOXIDANT AND CHOLINESTERASE INHIBITION POTENTIAL

Clinopodium vulgare L. (Lamiaceae) is widely distributed in Europe, Northwest Asia, North Africa and America. In ethnopharmacology of Bosnia and Herzegovina, C. vulgare is used in the treatment of gastrointestinal disorders. Bioactive components of extracts have an important role in the prevention and treatment of chronic diseases related to oxidative stress. One of them is Alzheimer's disease, the most common form of dementia. In the treatment of Alzheimer’s disease, ihibitors of cholinesterases are also used. Medicinal plants are potential source of cholinesterase inhibitors which is why they are subject of numerous research. The aim of this work was to determine chemical composition as well as antioxidant and anticholinesterase potential of C. vulgare hot water and methanol extracts. Using HPLC/DAD technique, rosmarinic acid, elagic acid, and ferulic acid were identified as dominant components of the extracts. The results of analyzed extracts showed good antioxidant activity tested by DPPH and FRAP assay. Inhibition of acetylcholinesterase and butyrylcholinesterase was determined using Ellman’s method. The obtained results showed low acetylcholinesterase inhibition potential and absence of butyrylcholinesterase inhibition.

Clinopodium vulgare, Extracts, Anticholinesterase potential, Antioxidant potential

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