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Pregled bibliografske jedinice broj: 1028643

The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition


Ćehić, Mirsada; Suć Sajko, Josipa; Karačić, Zrinka; Piotrowski, Patryciusz; Šmidlehner, Tamara; Jerić, Ivanka; Schmuck, Carsten; Piantanida, Ivo; Tomić, Sanja
The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition // Journal of biomolecular structure & dynamics, 38 (2020), 13; 3790-3800 doi:10.1080/07391102.2019.1664936 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1028643 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition

Autori
Ćehić, Mirsada ; Suć Sajko, Josipa ; Karačić, Zrinka ; Piotrowski, Patryciusz ; Šmidlehner, Tamara ; Jerić, Ivanka ; Schmuck, Carsten ; Piantanida, Ivo ; Tomić, Sanja

Izvornik
Journal of biomolecular structure & dynamics (0739-1102) 38 (2020), 13; 3790-3800

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DPP III inhibitor ; fluorescence ; pyrene ; cyanine ; guanidiniocarbonyl-pyrrole

Sažetak
Study of seven new guanidiniocarbonylpyrrole (GCP) - fluorophore conjugates interactions with dipeptidyl peptidase III (DPP III) showed that all compounds bind strongly (Ks ≈ µM) to enzyme active site, but with very different fluorimetric response (varying from quenching to strong increase), dependent on the fluorophore type and intramolecular pre-organisation of molecule. Positively charged lysine side chain improved significantly compound solubility but diminished fluorescence increase upon DPP III binding and completely abolished inhibitory effect on DPP III activity, whereas linker-neutral analogues showed stronger emission increase and were efficient enzyme inhibitors. By far the best fluorimetric response and inhibitive properties showed cyanine – GCP analogue, thus being promising lead compound for both, enzyme sensing and bio-activity inhibiting (theragnostic) studies of DPP III in the future.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-2936 - Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka (DPP3BioRe) (Tomić, Sanja, HRZZ - 2018-01) ( POIROT)
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Ćehić, Mirsada; Suć Sajko, Josipa; Karačić, Zrinka; Piotrowski, Patryciusz; Šmidlehner, Tamara; Jerić, Ivanka; Schmuck, Carsten; Piantanida, Ivo; Tomić, Sanja
The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition // Journal of biomolecular structure & dynamics, 38 (2020), 13; 3790-3800 doi:10.1080/07391102.2019.1664936 (međunarodna recenzija, članak, znanstveni)
Ćehić, M., Suć Sajko, J., Karačić, Z., Piotrowski, P., Šmidlehner, T., Jerić, I., Schmuck, C., Piantanida, I. & Tomić, S. (2020) The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition. Journal of biomolecular structure & dynamics, 38 (13), 3790-3800 doi:10.1080/07391102.2019.1664936.
@article{article, year = {2020}, pages = {3790-3800}, DOI = {10.1080/07391102.2019.1664936}, keywords = {DPP III inhibitor, fluorescence, pyrene, cyanine, guanidiniocarbonyl-pyrrole}, journal = {Journal of biomolecular structure and dynamics}, doi = {10.1080/07391102.2019.1664936}, volume = {38}, number = {13}, issn = {0739-1102}, title = {The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition}, keyword = {DPP III inhibitor, fluorescence, pyrene, cyanine, guanidiniocarbonyl-pyrrole} }
@article{article, year = {2020}, pages = {3790-3800}, DOI = {10.1080/07391102.2019.1664936}, keywords = {DPP III inhibitor, fluorescence, pyrene, cyanine, guanidiniocarbonyl-pyrrole}, journal = {Journal of biomolecular structure and dynamics}, doi = {10.1080/07391102.2019.1664936}, volume = {38}, number = {13}, issn = {0739-1102}, title = {The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition}, keyword = {DPP III inhibitor, fluorescence, pyrene, cyanine, guanidiniocarbonyl-pyrrole} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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