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Challenges and obstacles to study nano-bio interface

The use of nanotechnology for biomedical purposes promises great advancements in diagnostics and treatment of various diseases. However, prior to the application of nanomaterials to the human body, their safety and toxicity need to be thoroughly assessed. The physicochemical properties of nanomaterials are significantly altered upon contact with complex matrices, making their behaviour in a biological system difficult to predict. So far, most methods applied to the study of nano-bio interactions suffer from the inability to accurately model the real-world conditions, as well as the huge variety of nanomaterials, the complexity of their characterization and their tendency to interfere with testing systems. The development of standardised, reproducible assays and the elimination of uncertainty regarding nanomaterial interactions is the next big step towards the safe and effective nanomedical treatment systems.

nanoparticles ; biomedicine ; nano-bio interface

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