engleski

lipids, and apolipoproteins in menopausal women on hormone replacement therapy

This study investigated the frequency of angiotensin-converting enzyme (ACE) genotypes, concentrations of total cholesterol(T-C), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), lipoprotein Lp(a), established risk factors(ERF) ratio (total cholesterol/HDL-C), apolipoproteins A-I, A-II, apoB and apo E in 134 menopausal women aged 49.62 +- 4.83 on oral hormone replacement therapy (HRT): 12 mg 17 beta-estradiol plus 1 mg noethisterone acetate/day, during 15.77 +- 9.94 months.In the present study assessment of the genetic, metabolic and environmental markers pointed to an intermediate risk of coronary heart disease in menopausal women on hormone replacement therapy, although the mechanism underlying the disease is not clear and well understood yet.

angiotensin-converting enzyme; gene polamorphism; lipids; apolipoproteins; menopausal women

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