engleski

Effect of clonidine on the cutaneous silent period during spinal anesthesia

Cutaneous silent period (CSP) is an oligosynaptic spinal inhibitory reflex. The results of our study show that intrathecal administration of levobupivacaine with added clonidine, in comparison to levobupivacaine alone, yields a significantly shorter CSP and a significantly longer CSP latency during block regression following subarachnoid block (SAB) application. Accordingly, we can conclude that during SAB regression, a small dose of intrathecally administered clonidine ameliorates the inhibitory tonus and accelerates the conduction in the oligosynaptic spinal circuit.

Clonidine, Local anesthetics, Nerve fibers, Spinal anesthesia, Reflex

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