engleski

Importance of solid state in prebiotic chemistry studies

Here, we have discovered that elusive pairing of methylated guanine and cytosine is readily available in the solid state by heating where the two nucleobases self-assemble via Watson- Crick hydrogen-bonding. Dry heating preserves DNA-specificity as a four-component mixture of nucleobases provides self-assembly only of complementary pairs. We thus emphasize the importance of the solid state as the reaction medium, even for the molecular self-assembly, which was thus far underexplored in the prebiotic context.

nucleobase pairing ; solid state ; prebiotic chemistry ; molecular self-assembly

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