3D-QSAR Analysis of Antioxidative Activity of Novel Heteroaromatic Amides (CROSBI ID 682076)
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Podaci o odgovornosti
Bertoša, Branimir ; Zlatović, Mario ; Hranjec, Marijana
engleski
3D-QSAR Analysis of Antioxidative Activity of Novel Heteroaromatic Amides
Using literature data on antioxidative activity, 3D-QSAR models were generated and usedto predict antioxidative acitivity of novel heteroaromatic amides. Volsurf1, 2 based proce-dure was used for generating QSAR models. Similar procedure was previously successfullyapplied to study different activities of diverse classes of compounds.3-4 Among compoundswhose antioxidative activities were predicted, 25 novel amidino substituted benzamideswere chosen for synthesis and experimental characterization. These compounds differregarding the variation of the heteroaromatic nuclei attached to the benzamide moietyand regarding the number of methoxy and/ or hydroxy substituents. Compounds were syn-thesized and their antioxidative activities were measured using two tests for antioxidativeactivity – DPPH and superoxide test. Compounds were also tested for antiproliferativeactivity in vitro against HeLa cells, as well as for antibacterial and antifungal activities, but compounds showed low to moderate antiproliferative and antimicrobial activities.However, the antioxidatiove activities were promising. Comparison of experimental andcomputationally predicted activities were obtained. Experiments confirmed QSAR pre-dictions since experimentally determined activities for all novel compounds are withinstandard deviation of error of prediction of the models used for predicting their activities.Further, QSAR analysis pointed to the molecular properties with the highest impact onantioxidative activity of novel heteroaromatic amides. Such information should be usefulfor the design of novel compounds with enhanced antioxidative activity.
3D-QSAR ; Antioxidative Activity ; Heteroaromatic Amides
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Podaci o prilogu
127-127.
2019.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
12th European Conference on Computational and Theoretical Chemistry
poster
01.09.2019-05.09.2019
Perugia, Italija