Organometallic derivatives of DNA bases (CROSBI ID 682031)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Toma, Mateja ; Šakić, Davor ; Lapić, Jasmina ; Djaković, Senka ; Vrček, Valerije
engleski
Organometallic derivatives of DNA bases
Organometallic derivatives of nucleobases (OrDeNs) belong to the new generation of conjugates in which metallocenes are linked to the basic structural elements of heredity. Nucleosides in which sugar part is replaced with organometallic moiety, such as ferrocene, combine electro- and bio-active fragments and are of use in (bio)analytical chemistry, and in medicinal chemistry since they are shown to exhibit anticancer and antibacterial activity. An attractive feature of ferrocene is that the vertical distance between the two Cp rings in ferrocene is 0.35 nm, which is similar to the distance between the stacked base pairs in DNA. These could provide useful building blocks in supramolecular chemistry coupling molecular recognition derived from DNA bases with electrochemistry from the redox active ferrocene, leading to the novel applications for the electrochemical recognition of a DNA/RNA binding substrates.
organometallics, ferrocene, nucleobases
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Podaci o prilogu
67-68.
2019.
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objavljeno
978-953-97333-6-8
Podaci o matičnoj publikaciji
Humboldt College, SCIENCE AND EDUCATIONAL CHALLENGES FACING EUROPE IN THE NEXT DECADE
Ivanda, Mile ; Skenderović, Hrvoje
Zagreb: Klub hrvatskih humboldtovaca
Podaci o skupu
Humboldt College: Science and educational challenges facing Europe in the next decade, On the occasion of the 250th anniversary of the birth of Alexander von Humboldt (1769-1859)
poster
10.10.2019-11.10.2019
Zagreb, Hrvatska