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Pregled bibliografske jedinice broj: 102606

Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules


Mahmutefendić, Hana; Kučić, Natalia; Lučin, Pero
Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules // American journal of reproductive immunology, 48 (2002), 2; 87-96 (međunarodna recenzija, članak, znanstveni)


Naslov
Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules

Autori
Mahmutefendić, Hana ; Kučić, Natalia ; Lučin, Pero

Izvornik
American journal of reproductive immunology (1046-7408) 48 (2002), 2; 87-96

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Sažetak
PROBLEM: To characterize the constitutive internalization of major histocompatibility complex (MHC) class I molecules, we have studied the expression of completely conformed (full) and unconformed (empty) L(d) molecules on non-polarized murine P815 cells. METHODS OF STUDY: Spontaneous endocytosis of L(d) molecules was induced by cycloheximide, an inhibitor of protein synthesis, and their disappearance from the cell surface was determined by flow cytometry. In order to investigate the mechanism of internalization, a palette of inhibitors of endocytosis and vesicular transport was used. RESULTS: Inhibitors of clathrine endocytosis did not influence the internalization of L(d) molecules. Inhibitors of caveolar endocytosis and inhibitors of endolysosomal degradation prevented down-regulation of empty, but not of full L(d) molecules. CONCLUSIONS: Empty L(d) molecules are internalized mostly by caveolar endocytosis and full L(d) molecules use a different pathway, neither clathrine-mediated nor caveolar. After internalization, full L(d) molecules are probably degraded and empty L(d) molecules recycle between endosomal compartment and the cell surface before they enter into the degradation compartment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0062030

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Mahmutefendić, Hana; Kučić, Natalia; Lučin, Pero
Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules // American journal of reproductive immunology, 48 (2002), 2; 87-96 (međunarodna recenzija, članak, znanstveni)
Mahmutefendić, H., Kučić, N. & Lučin, P. (2002) Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules. American journal of reproductive immunology, 48 (2), 87-96.
@article{article, year = {2002}, pages = {87-96}, keywords = {}, journal = {American journal of reproductive immunology}, volume = {48}, number = {2}, issn = {1046-7408}, title = {Distinct pathways for constitutive endocytosis of fully conformed and non-conformed L(d) molecules}, keyword = {} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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