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Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins


(CA Environment and Genetics UATLX-CA-223) Arenas-Huertero, Francisco; Zaragoza-Ojeda, Montserrat; Sánchez-Alarcón, Juana; Milić, Mirta; Šegvić Klarić, Maja; Montiel-González, Jose M; Valencia-Quintana, Rafael
Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins // Frontiers in Microbiology, 10 (2019), 2347, 15 doi:10.3389/fmicb.2019.02347 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins

Autori
Arenas-Huertero, Francisco ; Zaragoza-Ojeda, Montserrat ; Sánchez-Alarcón, Juana ; Milić, Mirta ; Šegvić Klarić, Maja ; Montiel-González, Jose M ; Valencia-Quintana, Rafael

Kolaboracija
CA Environment and Genetics UATLX-CA-223

Izvornik
Frontiers in Microbiology (1664-302X) 10 (2019); 2347, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Aspergillus, Alternaria, AFB1, alternariol (AOH), CYP1A1

Sažetak
The purpose of this review is to present information about the role of activation of aflatoxins and other mycotoxins, of the aryl hydrocarbon receptor (AhR) pathway. Aflatoxins and other mycotoxins are a diverse group of secondary metabolites that can be contaminants in a broad range of agricultural products and feeds. Some species of Aspergillus, Alternaria, Penicilium, and Fusarium are major producers of mycotoxins, some of which are toxic and carcinogenic. Several aflatoxins are planar molecules that can activate the AhR. AhR participates in the detoxification of several xenobiotic substances and activates phase I and phase II detoxification pathways. But it is important to recognize that AhR activation also affects differentiation, cell adhesion, proliferation, and immune response among others. Any examination of the effects of aflatoxins and other toxins that act as activators to AhR must consider the potential of the disruption of several cellular functions in order to extend the perception thus far about the toxic and carcinogenic effects of these toxins. There have been no Reviews of existing data between the relation of AhR and aflatoxins and this one attempts to give information precisely about this dichotomy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb

Citiraj ovu publikaciju

(CA Environment and Genetics UATLX-CA-223) Arenas-Huertero, Francisco; Zaragoza-Ojeda, Montserrat; Sánchez-Alarcón, Juana; Milić, Mirta; Šegvić Klarić, Maja; Montiel-González, Jose M; Valencia-Quintana, Rafael
Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins // Frontiers in Microbiology, 10 (2019), 2347, 15 doi:10.3389/fmicb.2019.02347 (međunarodna recenzija, pregledni rad, znanstveni)
(CA Environment and Genetics UATLX-CA-223) (CA Environment and Genetics UATLX-CA-223) Arenas-Huertero, F., Zaragoza-Ojeda, M., Sánchez-Alarcón, J., Milić, M., Šegvić Klarić, M., Montiel-González, J. & Valencia-Quintana, R. (2019) Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins. Frontiers in Microbiology, 10, 2347, 15 doi:10.3389/fmicb.2019.02347.
@article{article, year = {2019}, pages = {15}, DOI = {10.3389/fmicb.2019.02347}, chapter = {2347}, keywords = {Aspergillus, Alternaria, AFB1, alternariol (AOH), CYP1A1}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2019.02347}, volume = {10}, issn = {1664-302X}, title = {Involvement of Ahr Pathway in Toxicity of Aflatoxins and Other Mycotoxins}, keyword = {Aspergillus, Alternaria, AFB1, alternariol (AOH), CYP1A1}, chapternumber = {2347} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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