Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels (CROSBI ID 269682)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Rogina, Anamarija ; Šandrk, Nikolina ; Teruel-Biosca, Laura ; Antunović, Maja ; Ivanković, Marica ; Gallego Ferrer, Gloria
engleski
Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydroxyapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells.
gelatine ; hydroxyapatite ; injectable ; hydrogel ; rheology ; cytotoxicity
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Podaci o izdanju
33
2019.
325-335
objavljeno
0352-9568
1846-5153
10.15255/CABEQ.2019.1663
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne tehničke znanosti, Kemija, Kemijsko inženjerstvo