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Injectable biphasic calcium phosphate vs. bovine xenograft in Guided Bone Regeneration - a prospective randomized clinical trial (CROSBI ID 681848)

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Pejakić, Marija Injectable biphasic calcium phosphate vs. bovine xenograft in Guided Bone Regeneration - a prospective randomized clinical trial // Dies Doctorandum Book of Abstracts 2019. / Smolić, Martina (ur.). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2019. str. 66-67

Podaci o odgovornosti

Pejakić, Marija

engleski

Injectable biphasic calcium phosphate vs. bovine xenograft in Guided Bone Regeneration - a prospective randomized clinical trial

Introduction: Biomaterials for bone augmentation can be classified as bone substitute materials (allografts, xenografts, and alloplastic bone substitutes) and membranes for Guided Bone Regeneration (GBR), which is one of the most common methods used to promote bone regeneration in implant dentistry. Biphasic calcium phosphate is a mixture of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), of varying HA/β-TCP ratios, most commonly 60:40 and 70:30. Previous in vivo studies showed that injectable bone substitutes (I-BCP) based on β-TCP have osteoconductive properties. One clinical case on use of I-BCP in sinus-lift procedure was reported. However, currently, there are no clinical studies on the use I-BCP consisting of 60% HA and 40% β-TCP in GBR. In present study we want to asses histological properties of I-BCP in GBR. Hypothesis: This study hypothesizes that there are no differences in potential for bone regeneration between I-BCP and xenograft of bovine origin. Aims: 1. to examine the bone regenerative potential of an I-BCP and xenograft by assessing descriptive histological results of bone biopsy harvested from the place of implantation ; 2. to determine histomorphometrical results (percentage of residual biomaterial, percentage of the soft tissue and percentage of the new bone) in bone biopsy harvested from the place of implantation ; 3. to register wound healing complications. Participants and methods: At the first stage of study 40 healthy patients with inidication for Guided Bone Regeneration (GBR) will be enrolled in study. Following the debridement, in 20 patients socket is filled with injectable biphasic calcium phosphate (I-BCP) consisting of 60% hydroxyapatite (HA) and 40% beta- tricalcium phosphate (β-TCP), and in control group consisting of 20 patients socket will be filled with xenograft of bovine origin. In both groups a resorbable native collagen membrane is trimmed and adapted to cover the bone defect fully. The mucoperiosteal flap is readapted, and the wound is closed with single sutures. The sutures are removed after 10 days. Six months after the GBR, in the both groups the second stage of the study will start. In this stage, a re-entry procedure will be performed to harvest bone for histological analysis, and to place a dental implant. A trephine bur with an internal diameter of 2.5 mm will be used to harvest the bone from the central part of the pre-existing bone defect. Biopsies will go through the preparation process, cutting and coloring so the histological (qualitative and quantitative) analysis could be done. Research plan: This prospective randomized clinical study will be performed in the period between October 2018 and March 2020. Patients will be recruited in a Community Health Center in Osijek. To enter the study, patients need to provide written consent. All surgeries will be performed by one experienced oral surgeon. Expected scientific contribution: Sucessful bone augmentation and implant-supported prosthetic rehabilitation does not only depend on the clinical skills of the practitioner, but also on the appropriate choice and use of different biomaterials. The peculiarity of I- BCP is that their viscosity allows easy filling of the bone defect, which also reduces surgery time and the burden to the patient. The use of the I-BCP in augmentation procedures has been poorly investigated and currently there there are no published studies on the use I-BCP, so this study would be the first histological study on the usage of I-BCP in GBR.

biphasic calcium phosphate, xenograft, dental implantology, histology, histomorphometry

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Podaci o prilogu

66-67.

2019.

objavljeno

Podaci o matičnoj publikaciji

Dies Doctorandum Book of Abstracts 2019.

Smolić, Martina

Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek

978-953-7736-42-2

Podaci o skupu

Dies Doctorandum 2019

poster

30.09.2019-01.10.2019

Osijek, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti