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Pregled bibliografske jedinice broj: 102515

MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo


Krmpotić, Astrid; Busch, Dirk; Bubić, Ivan; Gebhardt, Friedemann; Hengel, Hartmut; Hasan, Milena; Scalzo, Anthony; Koszinowski, Ulrich H.; Jonjić, Stipan
MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo // Nature immunology, 3 (2002), 6; 529-535 (međunarodna recenzija, članak, znanstveni)


Naslov
MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo

Autori
Krmpotić, Astrid ; Busch, Dirk ; Bubić, Ivan ; Gebhardt, Friedemann ; Hengel, Hartmut ; Hasan, Milena ; Scalzo, Anthony ; Koszinowski, Ulrich H. ; Jonjić, Stipan

Izvornik
Nature immunology (1529-2908) 3 (2002), 6; 529-535

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Sažetak
The susceptibility of certain inbred mouse strains to murine cytomegalovirus (MCMV) is related to their inability to generate a strong natural killer (NK) cell response. We addressed here whether the MCMV susceptibility of the BALB/c strain is due to viral functions that control NK cell activation in a strain-specific manner. MCMV expresses two proteins, gp48 and gp40, that are encoded by the genes m06 and m152, respectively ; they down-regulate major histocompatibility complex (MHC) class I expression at the plasma membrane. Using MCMV deletion mutants and revertants, we found that gp40 but not gp48 controls NK cell activation. Absence of gp40 improved antiviral NK cell control in BALB/c, but not C57BL/6, mice. Down-regulation of H-60, the high-affinity ligand for the NKG2D receptor, was the mechanism by which gp40 modulates NK cell activation. Thus, a single herpesvirus protein has a dual function in inhibiting both the adaptive as well as the innate immune response.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Projekt / tema
062004
062005

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Milena Hasan (autor)

Avatar Url Astrid Krmpotić (autor)

Avatar Url Ivan Bubić (autor)

Avatar Url Stipan Jonjić (autor)

Citiraj ovu publikaciju

Krmpotić, Astrid; Busch, Dirk; Bubić, Ivan; Gebhardt, Friedemann; Hengel, Hartmut; Hasan, Milena; Scalzo, Anthony; Koszinowski, Ulrich H.; Jonjić, Stipan
MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo // Nature immunology, 3 (2002), 6; 529-535 (međunarodna recenzija, članak, znanstveni)
Krmpotić, A., Busch, D., Bubić, I., Gebhardt, F., Hengel, H., Hasan, M., Scalzo, A., Koszinowski, U. & Jonjić, S. (2002) MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo. Nature immunology, 3 (6), 529-535.
@article{article, year = {2002}, pages = {529-535}, keywords = {}, journal = {Nature immunology}, volume = {3}, number = {6}, issn = {1529-2908}, title = {MCMV glycoprotein gp40 confers virus resistance to CD8+T cells and NK cells in vivo}, keyword = {} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus